Park H W, Beese L S
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Curr Opin Struct Biol. 1997 Dec;7(6):873-80. doi: 10.1016/s0959-440x(97)80160-1.
In the past year, the crystal structure of alpha beta heterodimeric protein farnesyltransferase from rat was reported to a resolution of 2.25 A. Farnesyltransferase catalyzes the essential post-translational lipidation of Ras and several other cellular signal transduction proteins. The structure provides a foundation for understanding the specificity and mechanism of protein prenylation and may aid in the design of new anticancer therapeutics.
去年，大鼠αβ异二聚体蛋白法尼基转移酶的晶体结构被报道，分辨率达到2.25埃。法尼基转移酶催化Ras和其他几种细胞信号转导蛋白进行必不可少的翻译后脂化修饰。该结构为理解蛋白质异戊二烯化的特异性和机制奠定了基础，并可能有助于新型抗癌疗法的设计。
