呼吸道合胞病毒ts-1突变体在限制温度下的生长及遗传稳定性
Growth and genetic stability of the ts-1 mutant of respiratory syncytial virus at restrictive temperatures.
作者信息
Schnitzer T J, Richardson L S, Chanock R M
出版信息
J Virol. 1976 Feb;17(2):431-8. doi: 10.1128/JVI.17.2.431-438.1976.
Abstract
An in vitro study was performed to define in greater detail those factors which favored the growth of the ts-1 mutant of respiratory syncytial virus under restrictive conditions and the emergence of genetically altered virus with decreased temperature sensitivity. Replication of ts-1 occurred at each of the restrictive temperatures of 37, 38, and 39 C, even through plaque formation was not observed. The level of virus growth under restrictive conditions was inversely related to the incubation temperature and directly related to the multiplicity of infection. These relationships appeared to reflect the effect of restrictive temperature in reducing the quantity of virus produced and released from an infected cell. Under restrictive conditions the production of genetically altered virus which exhibited reduced temperature sensitivity was directly related to the multiplicity of infection and inversely related to temperature. Production of genetically altered virus was not observed under permissive conditions.
摘要
进行了一项体外研究，以更详细地确定在限制条件下有利于呼吸道合胞病毒ts-1突变体生长以及出现温度敏感性降低的基因改变病毒的那些因素。即使未观察到空斑形成，ts-1在37、38和39℃的每个限制温度下均发生复制。限制条件下的病毒生长水平与孵育温度呈负相关，与感染复数呈正相关。这些关系似乎反映了限制温度对减少从感染细胞产生和释放的病毒量的影响。在限制条件下，表现出温度敏感性降低的基因改变病毒的产生与感染复数呈正相关，与温度呈负相关。在允许条件下未观察到基因改变病毒的产生。
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