呼吸道合胞病毒温度敏感突变体的七个互补群
Seven complementation groups of respiratory syncytial virus temperature-sensitive mutants.
作者信息
Gimenez H B, Pringle C R
出版信息
J Virol. 1978 Sep;27(3):459-64. doi: 10.1128/JVI.27.3.459-464.1978.
Abstract
Fifteen temperature-sensitive mutants of the RSN-2 strain of respiratory syncytial virus have been classified into six complementation groups, two of which appeared to be homologous with two of the three complementation groups of the A2 strain described by Wright et al. (P. F. Wright, M. A. Gharpure, D. S. Hodes, and R. M. Chanock, Arch. Gesamte Virusforsch, 41:238--247). Thus seven complementation groups of respiratory syncytial virus, designated A, B, C, D, E, F, and G, have been defined. The frequency and type of mutant isolated varied according to strain; group C was unique to the A2 strain, and groups D, E, F, and G were unique to the RSN-2 strain. The highest complementation indexes were obtained by preincubation for 7 h at permissive temperature, followed by incubation at restrictive temperature for 40 to 50 h in the case of A2 strain mutants or 80 to 90 h for RSN-2 strain mutants. Genetic recombination was not detected.
摘要
呼吸道合胞病毒RSN - 2株的15个温度敏感突变体已被分为6个互补组，其中两组似乎与赖特等人描述的A2株的三个互补组中的两个同源（P.F.赖特、M.A.加尔普尔、D.S.霍兹和R.M.查诺克，《病毒学研究综述》，41:238 - 247）。因此，已确定了呼吸道合胞病毒的7个互补组，分别命名为A、B、C、D、E、F和G。分离出的突变体的频率和类型因毒株而异；C组是A2株特有的，而D、E、F和G组是RSN - 2株特有的。对于A2株突变体，在允许温度下预孵育7小时，然后在限制温度下孵育40至50小时，对于RSN - 2株突变体则孵育80至90小时，可获得最高互补指数。未检测到基因重组。
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