用3'-脱氧腺苷处理的鸡胚细胞胞质中的流感病毒RNA。
Influenza virus RNA's in the cytoplasm of chicken embryo cells treated with 3'-deoxyadenosine.
作者信息
Pridgen C L
出版信息
J Virol. 1976 Apr;18(1):356-60. doi: 10.1128/JVI.18.1.356-360.1976.
Abstract
3'-Deoxyadenosine (75 to 100 mug/ml) permitted analysis of the cytoplasmic influencza virus-specific RNAs synthesized early in the replicative cycle-a phase that has hitherto been obscurred by host cell RNA synthesis. In addition, late in the cycle (6 to 8) complementary virus-specific RNA's were the predominantly labeled species, suggesting that higher concentrations of 3'-deoxyadenosine selectively inhibit influenza viral genome replication.
摘要
3'-脱氧腺苷（75至100微克/毫升）使得能够分析在复制周期早期合成的细胞质流感病毒特异性RNA，这一阶段迄今为止一直被宿主细胞RNA合成所掩盖。此外，在周期后期（6至8小时），互补的病毒特异性RNA是主要被标记的种类，这表明较高浓度的3'-脱氧腺苷选择性地抑制流感病毒基因组复制。
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