Wang Li, Yan Huanhuan, Zeng Bin, Hu Zhihong
Jiangxi Key Laboratory of Bioprocess Engineering, College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China.
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Bioengineering (Basel). 2022 Feb 11;9(2):69. doi: 10.3390/bioengineering9020069.
is an insect-born fungus that belongs to and . It has a variety of biological activities that can be applied in medicine, health-care products, cosmeceuticals and other fields. Cordycepin (COR) is one of the major bioactive components identified from . Thus, and COR have attracted extensive attention. In this study, chemical synthetic methods and the biosynthesis pathway of COR were reviewed. As commercially COR was mainly isolated from fermentation, the optimizations for liquid and solid fermentation and genetic modifications of to increase COR content were also summarized. Moreover, the research progress of genetic modifications of and methods for separation and purification COR were introduced. Finally, the existing problems and future research direction of were discussed. This study provides a reference for the production of COR in the future.
是一种虫生真菌，属于……。它具有多种生物活性，可应用于医药、保健品、药妆品等领域。虫草素（COR）是从……中鉴定出的主要生物活性成分之一。因此，……和COR引起了广泛关注。本研究综述了COR的化学合成方法和生物合成途径。由于商业上COR主要从……发酵中分离得到，还总结了液体和固体发酵的优化以及……的基因改造以提高COR含量。此外，介绍了……基因改造的研究进展以及COR的分离纯化方法。最后，讨论了……存在的问题和未来研究方向。本研究为未来COR的生产提供了参考。
