通过与灵长类红细胞补体受体结合的双特异性单克隆抗体介导的血源性病原体清除。
Clearance of blood-borne pathogens mediated through bispecific monoclonal antibodies bound to the primate erythrocyte complement receptor.
作者信息
Taylor R P, Nardin A, Sutherland W M
机构信息
Department of Biochemistry, University of Virginia School of Medicine, Charlottesville 22908, USA.
出版信息
Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):152-5. doi: 10.1007/s002620050420.
The primate erythrocyte complement receptor facilitates both the immune adherence reaction and the immune complex clearance properties of primate erythrocytes. These phenomena have been studied for more than 40 years. However, it has only recently become apparent that these characteristics of primate erythrocytes may be useful in the generation of a therapy based on bispecific monoclonal antibodies. Our approach uses bispecific monoclonal antibody constructs (heteropolymers) that promote binding of specific target pathogens to primate erythrocytes via the complement receptor. Once bound to the erythrocytes, the pathogen-heteropolymer complex should be cleared from the circulation, phagocytosed and destroyed in the liver. Results with several prototype target pathogens in monkey models indicate it may be possible to use this technology to develop a robust and general therapy for the treatment of diseases associated with blood-borne pathogens.
灵长类动物红细胞补体受体促进灵长类动物红细胞的免疫黏附反应和免疫复合物清除特性。这些现象已经研究了40多年。然而，直到最近才明显发现，灵长类动物红细胞的这些特性可能有助于开发基于双特异性单克隆抗体的疗法。我们的方法使用双特异性单克隆抗体制剂（异聚物），通过补体受体促进特定目标病原体与灵长类动物红细胞的结合。一旦与红细胞结合，病原体-异聚物复合物应从循环中清除，在肝脏中被吞噬并破坏。在猴子模型中对几种原型目标病原体的研究结果表明，利用这项技术有可能开发出一种强大而通用的疗法，用于治疗与血源性病原体相关的疾病。
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