Lukkarinen O, Hellström P, Leppilahti M, Kontturi M, Tammela T
Department of Surgery, Oulu University Hospital, Finland.
Ann Chir Gynaecol. 1997;86(3):239-42.
The risk of severe infection and complications in connection with transurethral resection of the prostate (TURP) has clearly increased in patients with urinary retention and an indwelling catheter. The aim of this study was to determine whether the antibiotics ciprofloxacin and ceftazidime are equally efficient in preventing infective complications in these patients.
An open randomized prospective study was carried out on 72 patients with urinary retention undergoing TURP, to compare of 500 mg of ciprofloxacin (CF) orally twice daily and 1 g of ceftazidime (CT) intravenously twice daily.
The incidence of early complications was 26% in the CF group and 17% in the CT group. All the complications were minor. On removal of the indwelling catheter, a positive urinary culture was detected in 6% of the patients in the CF group and in 3% in the CT group. One month after TURP, a positive urinary culture was detected in 14% of the patients in the CF group and in 18% of the CT group.
It is concluded that both of the antibiotics used in this trial were equally effective in the prevention of early urinary and other infections and also late complications, in patients with urinary retention undergoing TURP.
对于存在尿潴留且留置导尿管的患者，经尿道前列腺切除术（TURP）相关的严重感染及并发症风险明显增加。本研究的目的是确定环丙沙星和头孢他啶这两种抗生素在预防这些患者感染性并发症方面是否同样有效。
对72例接受TURP的尿潴留患者进行了一项开放性随机前瞻性研究，比较每日口服两次500毫克环丙沙星（CF）与每日静脉注射两次1克头孢他啶（CT）的效果。
CF组早期并发症发生率为26%，CT组为17%。所有并发症均为轻度。拔除留置导尿管时，CF组6%的患者尿培养呈阳性，CT组为3%。TURP术后1个月，CF组14%的患者尿培养呈阳性，CT组为18%。
得出的结论是，在接受TURP的尿潴留患者中，本试验中使用的两种抗生素在预防早期泌尿系统及其他感染以及晚期并发症方面同样有效。
