Mohler J L, Williams B T, Freeman J A
Department of Surgery, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.
World J Urol. 1997;15(6):364-8. doi: 10.1007/BF01300184.
The outcome of patients selecting observation of clinical stage T1c prostate cancer is unknown. A total of 101 men with clinical stage T1c prostate cancer were evaluated, counseled, and monitored in a standard fashion. Altogether, 27 men who elected observation were older and had greater co-morbidity but similar tumor characteristics as compared with 74 men who elected radical prostatectomy. In all, 9 men demonstrated clinical or biochemical evidence of progression after a mean follow-up of 23 months; 4 men who underwent radical prostatectomy had specimen-confined disease and undetectable post-operative levels of PSA. Observation appears to be a viable option for some men with clinical stage T1c prostate cancer.
临床分期为T1c期前列腺癌患者选择观察等待的结果尚不清楚。共有101例临床分期为T1c期的前列腺癌男性患者接受了标准方式的评估、咨询和监测。总体而言，与74例选择根治性前列腺切除术的男性相比，选择观察等待的27例男性年龄更大且合并症更多，但肿瘤特征相似。平均随访23个月后，共有9例男性出现临床或生化进展证据；4例接受根治性前列腺切除术的男性标本切缘阴性且术后PSA水平检测不到。对于一些临床分期为T1c期的前列腺癌男性患者来说，观察等待似乎是一种可行的选择。
