Binhazim A A, Lee D R, Bernacky B J, Rizvi T A
Department of Veterinary Sciences, University of Texas M.D. Anderson Cancer Center, Bastrop 78602, USA
J Med Primatol. 1997 Oct;26(5):260-6. doi: 10.1111/j.1600-0684.1997.tb00221.x.
An anaplastic large cell lymphoma with disseminated abdominal metastases was diagnosed in a 35-year-old male chimpanzee. Clinically, the animal displayed lethargy, weight loss, ascites, and abdominal distention. Imaging studies showed several large abdominal masses. At necropsy, variably sized masses of neoplastic mesenteric lymph nodes that encompassed several intestinal loops were present throughout the abdomen. The largest mass measured 9 x 5 cm and had cauliflower-like protrusions into the jejunal lumen. The entire abdominal cavity was covered by a sheet of neoplastic tissue. Histopathologically, the tumor consisted of solid sheets of proliferating lymphoid cells forming a cohesive growth that filled the lymph node sinuses. The tumor had invaded the intestinal wall. Anaplastic large cell lymphoma was diagnosed from immunohistochemistry findings on the basis of positive reaction to the CD3 and CD30 markers and negative reaction to the CD20 marker. Serologic analysis revealed positive titers for Epstein-Barr, cytomegalo-, and varicella-zoster viruses. Both serologic and virologic studies showed no evidence of detectable retroviral infection. This type of tumor has not been reported before in the chimpanzee.
一只35岁的雄性黑猩猩被诊断出患有伴有弥漫性腹部转移的间变性大细胞淋巴瘤。临床上,这只动物表现出嗜睡、体重减轻、腹水和腹胀。影像学检查显示腹部有几个大肿块。尸检时,整个腹部都存在大小不一的肿瘤性肠系膜淋巴结肿块,包绕着几个肠袢。最大的肿块尺寸为9×5厘米,向空肠腔内呈菜花状突出。整个腹腔被一层肿瘤组织覆盖。组织病理学检查显示,肿瘤由增殖的淋巴细胞实性片层组成,形成紧密生长,充满淋巴结窦。肿瘤已侵犯肠壁。根据免疫组化结果,对CD3和CD30标记物呈阳性反应,对CD20标记物呈阴性反应,诊断为间变性大细胞淋巴瘤。血清学分析显示,爱泼斯坦-巴尔病毒、巨细胞病毒和水痘-带状疱疹病毒的滴度呈阳性。血清学和病毒学研究均未显示可检测到的逆转录病毒感染迹象。这种类型的肿瘤此前在黑猩猩中尚未有过报道。