黑猩猩（Pan属）的肿瘤形成。
Neoplasia in the chimpanzee (Pan spp.).
作者信息
Brown S L, Anderson D C, Dick E J, Guardado-Mendoza R, Garcia A P, Hubbard G B
机构信息
Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
出版信息
J Med Primatol. 2009 Apr;38(2):137-44. doi: 10.1111/j.1600-0684.2008.00321.x.
BACKGROUND
Chimpanzees have over 98% genomic sequence homology with humans and may have a similar host response to malignancy. There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research.
METHODS
Spontaneous neoplasia that was documented in two chimpanzee colonies and in the literature were evaluated statistically.
RESULTS
In all, 105 spontaneous and 12 experimental neoplasms were diagnosed. Seventy-four spontaneous tumors occurred in females, 24 in males,and seven in animals of undetermined sex. Of the spontaneous tumors 89 were benign, 14 were malignant, and two were undetermined. Neoplasia was most common in the urogenital system in females.
CONCLUSIONS
Neoplasia is not uncommon in the chimpanzee, is generally benign, and occurs primarily in the urogenital system in females.
背景
黑猩猩与人类有超过98%的基因组序列同源性，并且对恶性肿瘤可能有类似的宿主反应。关于黑猩猩癌症的信息极少，而这些信息对于照顾它们并将其用于研究的人员来说将是有价值的。
方法
对两个黑猩猩群体中记录的以及文献中的自发性肿瘤进行统计学评估。
结果
总共诊断出105例自发性肿瘤和12例实验性肿瘤。74例自发性肿瘤发生在雌性黑猩猩中，24例发生在雄性黑猩猩中，7例发生在性别未确定的动物中。在自发性肿瘤中，89例为良性，14例为恶性，2例性质未确定。肿瘤在雌性黑猩猩的泌尿生殖系统中最为常见。
结论
肿瘤在黑猩猩中并不罕见，通常为良性，并且主要发生在雌性黑猩猩的泌尿生殖系统中。
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