Tsenghi C, Metaxotou-Stavridaki C, Strataki-Benetou M, Kalpini-Mavrou A, Matsaniotis N
Obstet Gynecol. 1976 Apr;47(4):463-8.
Karyotypes were prepared from peripheral blood leukocytes in 77 couples in whom there was no apparent cause for recurrent spontaneous abortion. In addition to conventional staining, chromosomes were stained by the new technics for Q-, G-, or C-banding. Translocations were found in 5 of 154 persons (3.25% or 1:31 individuals). The frequency of translocations in the general adult population is 0.4% (1:255). Two translocations were apparent only with the new technics for banding. The incidence of chromosomal microanomalies was 7.79% (2.6% in the general population). Karyotyping of couples with recurrent abortion is recommended, with use of the new staining technics.
对77对反复自然流产但无明显病因的夫妇，采集其外周血白细胞制备核型。除常规染色外，还采用Q带、G带或C带新技术对染色体进行染色。154人中发现5人存在易位（3.25%或1:31个体）。普通成年人群中易位频率为0.4%（1:255）。仅用染色体显带新技术才发现2例易位。染色体微异常发生率为7.79%（普通人群中为2.6%）。建议对反复流产的夫妇进行核型分析，并采用新的染色技术。
