Qian Wei-Ping, Tan Yu-Mei, Song Dan, Tan Yue-Qiu, Lu Guang-Xiu
Reproductive Medical Center, Luohu Hospital, Shenzhen 518001, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun;30(3):258-60.
To explore the relationship between chromosome anomaly and spontaneous abortion, and to provide useful information for genetic counseling and prenatal diagnosis in reproductive clinic.
A total of 1 780 patients who had a history of spontaneous abortion before 24 weeks of gestation were enrolled. The lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- banding in some cases in addition.
Altogether 57 abnormal karyotypes were found and the overall incidence of chromosomal abnormalities was 3.20% (women 3.32%; men 2.12%). Among them 23 cases were the balanced translocation; 14 cases were the Robertsonian translocation, 3 cases were the complex chromosomal rearrangement, and the other 17 cases were the other abnormalities. In women with 1, 2, 3 or more spontaneous abortion, the incidence of chromosomal abnormalities was 1.7%, 2.3%, and 5.8%, respectively.
Translocations are the major abnormal karyotpes associated with spontaneous abortions. The chance of finding chromosomal aberration increases with the number of abortions. Chromosomal abnormalities are more common in women with 3 or more spontaneous abortions.
探讨染色体异常与自然流产之间的关系，为生殖门诊的遗传咨询和产前诊断提供有用信息。
纳入1780例妊娠24周前有自然流产史的患者。按照标准方法进行淋巴细胞培养和收获。所有病例均采用G显带分析核型，部分病例还采用C显带分析。
共发现57例异常核型，染色体异常的总发生率为3.20%（女性为3.32%；男性为2.12%）。其中23例为平衡易位；14例为罗伯逊易位，3例为复杂染色体重排，其他17例为其他异常。在有1次、2次、3次或更多次自然流产的女性中，染色体异常的发生率分别为1.7%、2.3%和5.8%。
易位是与自然流产相关的主要异常核型。发现染色体畸变的几率随流产次数增加而增加。染色体异常在有3次或更多次自然流产的女性中更为常见。
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