Cömlekçi A, Biberoglu S, Kozan O, Bahçeci O, Ergene O, Nazli C, Kinay O, Güner G
Department of Internal Medicine, Dokuz Eylül University, Medical School, Inciralti, Izmir, Turkey.
J Intern Med. 1997 Dec;242(6):449-54. doi: 10.1111/j.1365-2796.1997.tb00017.x.
To examine the impact of diabetic state on the concentrations of lipoprotein(a) [Lp(a)] in patients with non-insulin-dependent diabetes mellitus (NIDDM) and the correlation between angiographic coronary artery disease (CAD) and serum Lp(a) concentrations in NIDDM.
In this cross-sectional study of 26 patients with NIDDM and 19 nondiabetic sex- and age-matched patients who underwent coronary angiography. CAD was assessed visually using coronary artery score (CAS), and plasma Lp(a) was measured by an enzyme-linked immunosorbent assay.
The study was performed in an internal medicine clinic at a university hospital.
Twenty-six age- and sex-matched patients with NIDDM and 19 control patients without diabetes.
There was no significant difference between the Lp(a) concentrations of patients with NIDDM and nondiabetic subjects (P > 0.05). When patients with NIDDM were stratified by absence or presence of CAD, patients with CAD had higher levels of Lp(a) (P < 0.05). However, there was no significant correlation between the concentrations of Lp(a) and CAS (P > 0.05).
Diabetic state does not have any impact on Lp(a) concentrations. Lp(a) excess seems to be atherogenic in patients with NIDDM as shown in nondiabetic patients in previous studies. Although diabetic patients with CAD have higher Lp(a) concentrations than the diabetic patients without CAD, Lp(a) levels were not correlated with CAS.
研究非胰岛素依赖型糖尿病（NIDDM）患者的糖尿病状态对脂蛋白(a)[Lp(a)]浓度的影响，以及NIDDM患者冠状动脉造影显示的冠心病（CAD）与血清Lp(a)浓度之间的相关性。
这是一项横断面研究，纳入了26例接受冠状动脉造影的NIDDM患者和19例年龄及性别匹配的非糖尿病患者。使用冠状动脉评分（CAS）直观评估CAD，并通过酶联免疫吸附测定法测量血浆Lp(a)。
该研究在一所大学医院的内科门诊进行。
26例年龄及性别匹配的NIDDM患者和19例无糖尿病的对照患者。
NIDDM患者与非糖尿病受试者的Lp(a)浓度无显著差异（P>0.05）。当根据有无CAD对NIDDM患者进行分层时发现，CAD患者的Lp(a)水平较高（P<0.05）。然而，Lp(a)浓度与CAS之间无显著相关性（P>0.05）。
糖尿病状态对Lp(a)浓度没有任何影响。如先前研究在非糖尿病患者中所示，Lp(a)升高似乎在NIDDM患者中具有致动脉粥样硬化作用。虽然患有CAD的糖尿病患者的Lp(a)浓度高于无CAD的糖尿病患者，但Lp(a)水平与CAS不相关。
