Nomura S, Fujitaka M, Sakura N, Ueda K
Department of Pediatrics, Hiroshima University School of Medicine, Japan.
Clin Chim Acta. 1997 Oct 31;266(2):83-91. doi: 10.1016/s0009-8981(97)00142-3.
We evaluated the circadian rhythms in the plasma concentrations of cortisol, cortisone and their free forms, and in the cortisone/cortisol ratios by means of reversed-phase high performance liquid chromatography in normal adult subjects. Plasma concentrations of cortisone, as well as cortisol, exhibited a circadian rhythm. The ratios of cortisone/cortisol remained almost constant during the waking hours of normal subjects. Changes in the cortisone/cortisol ratios previously reported in patients with various diseases exceeded the diurnal changes detected in the present study. Thus, the determination of the cortisone/cortisol ratio provides information that is useful in assessing the adrenal function of patients with various diseases.
我们通过反相高效液相色谱法评估了正常成年受试者血浆中皮质醇、可的松及其游离形式的浓度昼夜节律，以及可的松/皮质醇比值。可的松和皮质醇的血浆浓度均呈现昼夜节律。在正常受试者的清醒时间内，可的松/皮质醇比值几乎保持恒定。先前报道的各种疾病患者的可的松/皮质醇比值变化超过了本研究中检测到的昼夜变化。因此，测定可的松/皮质醇比值可提供有助于评估各种疾病患者肾上腺功能的信息。
