Barker D J
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
Theriogenology. 2000 Jan 15;53(2):555-74. doi: 10.1016/s0093-691x(99)00258-7.
Low birth weight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished. These adaptations may be cardiovascular, metabolic or endocrine. They permanently change the structure and function of the body. Prevention of the diseases may depend on prevention of imbalances in fetal growth or imbalances between pre- and post-natal growth, or imbalances in nutrient supply to the fetus.
现在已知出生时低体重、消瘦和身长较短与成年后患心血管疾病和非胰岛素依赖型糖尿病的几率增加有关。胎儿起源假说提出，这些疾病源于胎儿在营养不良时所做出的适应性变化。这些适应性变化可能是心血管方面的、代谢方面的或内分泌方面的。它们会永久性地改变身体的结构和功能。预防这些疾病可能取决于预防胎儿生长失衡、产前和产后生长失衡或胎儿营养供应失衡。
