Gardell L R, Reid L D, Boedeker K L, Liakos T M, Hubbell C L
Laboratory for Psychopharmacology, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, USA.
Alcohol Clin Exp Res. 1997 Dec;21(9):1592-8.
Individually housed rats were placed on a daily regimen of only 2 hr a day to drink both water and a sweetened alcoholic beverage. Initially, rats took little ethanol, but after 3 weeks, they took, on average, >2.0 g/kg daily. With achievement of stable intakes, the rats were deprived of opportunity to drink ethanol for 24 days and then the daily regimen was reinstated. With the reinstatement, various injections were given daily for 25 days or more: placebos, doses of isradipine (1.0 or 3.0 mg/kg), naltrexone (3.0 mg/kg), and a combination of isradipine (1.0 mg/kg) and naltrexone (3.0 mg/kg). The combination produced favorable effects with the fewest limiting side-effects. The period of abstinence decreased daily intakes of ethanol and interacted with the drugs to produce large, sustained decreases in intakes of ethanol.
单独饲养的大鼠每天仅被给予2小时的时间来饮用清水和一种加了甜味剂的酒精饮料。最初，大鼠摄入的乙醇很少，但3周后，它们平均每天摄入超过2.0克/千克的乙醇。在摄入量稳定后，大鼠被剥夺饮用乙醇的机会24天，然后恢复每日的饮食方案。恢复饮食方案后，每天进行各种注射，持续25天或更长时间：安慰剂、不同剂量的伊拉地平（1.0或3.0毫克/千克）、纳曲酮（3.0毫克/千克）以及伊拉地平（1.0毫克/千克）和纳曲酮（3.0毫克/千克）的组合。这种组合产生了有利的效果，且副作用最少。禁欲期减少了乙醇的每日摄入量，并与药物相互作用，使乙醇摄入量大幅持续下降。
