Hall A
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK.
Science. 1998 Jan 23;279(5350):509-14. doi: 10.1126/science.279.5350.509.
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
肌动蛋白细胞骨架在所有真核细胞中介导多种重要的生物学功能。除了提供一个定义细胞形状和极性的结构框架外，其动态特性还为细胞移动和分裂提供驱动力。因此，了解控制肌动蛋白组织的生化机制是当代细胞生物学的一个主要目标，这对健康和疾病都有影响。小GTP酶Rho家族的成员已成为肌动蛋白细胞骨架的关键调节因子，此外，通过与多种靶蛋白的相互作用，它们确保对其他细胞活动如基因转录和黏附的协调控制。
