Ridley A J
Ludwig Institute for Cancer Research, University College School of Medicine, London, UK.
Curr Opin Genet Dev. 1995 Feb;5(1):24-30. doi: 10.1016/s0959-437x(95)90049-7.
The past year has produced an abundance of data on the function and regulation of Rho-related GTP-binding proteins. In mammalian cells, it has been shown that Rho is required for contractile ring assembly at cell division, as well as for regulating extracellular factor induced actin reorganization. In addition, many new regulators and/or potential targets for Rho, Rac and Cdc42 have been characterized, including several oncogene products, protein kinases and signal transducing proteins in mammalian cells, and genes defined by cell cycle or bud emergence mutations in yeast. These provide further connections between Rho-related proteins, signal transduction pathways and changes in actin organization during cell cycle entry and progression.
过去一年产生了大量关于Rho相关GTP结合蛋白的功能和调控的数据。在哺乳动物细胞中，已表明Rho在细胞分裂时收缩环组装以及调节细胞外因子诱导的肌动蛋白重组中是必需的。此外，已鉴定出许多Rho、Rac和Cdc42的新调节因子和/或潜在靶点，包括哺乳动物细胞中的几种癌基因产物、蛋白激酶和信号转导蛋白，以及酵母中由细胞周期或芽出现突变定义的基因。这些进一步揭示了Rho相关蛋白、信号转导途径与细胞周期进入和进程中肌动蛋白组织变化之间的联系。
