Kajimura Y, Kaneda M
Central Research Laboratories, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
J Antibiot (Tokyo). 1997 Mar;50(3):220-8.
Fusaricidins B, C and D, new depsipeptide antibiotics, have been isolated as minor components from the culture broth of Bacillus polymyxa KT-8 which was obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. The structure of fusaricidin B has been elucidated mainly by various NMR experiments coupled with amino acid analysis in relation to fusaricidin A, the main component of the complex, whose structure was reported previously. The fraction consisting of fusaricidins C and D was unsuccessfully separated, giving roughly a 4:1 mixture of the two, respectively. The structures of fusaricidins C and D have been determined within the mixture by detailed analyses of the 2D NMR spectra. Fusaricidins B, C and D are active against fungi and Gram-positive bacteria almost as well as fusaricidin A.
新的缩肽抗生素镰刀菌素B、C和D是从多粘芽孢杆菌KT - 8的培养液中作为次要成分分离得到的，该菌株从患有尖孢镰刀菌引起的基腐病的大蒜根际获得。镰刀菌素B的结构主要通过各种核磁共振实验结合氨基酸分析得以阐明，该分析与该复合物的主要成分镰刀菌素A相关，其结构先前已被报道。由镰刀菌素C和D组成的馏分未能成功分离，大致得到二者4:1的混合物。通过对二维核磁共振谱的详细分析确定了混合物中镰刀菌素C和D的结构。镰刀菌素B、C和D对真菌和革兰氏阳性菌的活性几乎与镰刀菌素A相同。
