Tindle R W
Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital, Herston, Queensland, Australia.
Immunol Res. 1997;16(4):387-400. doi: 10.1007/BF02786401.
Three vaccine strategies that target human papillomavirus (HPV) are likely to be effective in the control of HPV-associated preneoplastic and neoplastic lesions of the uterine cervix. 1. Immunotherapy for HPV-associated cervical cancer targeted at two nonstructural PV proteins expressed in cancer cells (E6 and E7). 2. Vaccines against existing HPV infection and early premalignant lesions targeted at early viral proteins expressed in suprabasal stem cells of infected anogenital epithelium. 3. Prophylactic vaccines to prevent HPV infection involving immunization with genetically engineered virus-like particles to elicit neutralizing antibody. Strategies 1 and 2 will need to evoke cytotoxic T-cell (CTL) mediated responses.
三种针对人乳头瘤病毒（HPV）的疫苗策略可能对控制子宫颈HPV相关的癌前病变和肿瘤性病变有效。1. 针对癌细胞中表达的两种非结构PV蛋白（E6和E7）的HPV相关宫颈癌免疫疗法。2. 针对感染的肛门生殖器上皮上层干细胞中表达的早期病毒蛋白的现有HPV感染和早期癌前病变疫苗。3. 通过用基因工程病毒样颗粒免疫以引发中和抗体来预防HPV感染的预防性疫苗。策略1和2将需要引发细胞毒性T细胞（CTL）介导的反应。
