Stoelting R K, Peterson C
Anesth Analg. 1976 Mar-Apr;55(2):232-4. doi: 10.1213/00000539-197603000-00023.
Circulatory responses after thiamylal (4 mg/kg) and succinylcholine (SCh) (2 mg/kg) administration followed by direct laryngoscopy and tracheal intubation were measured in 20 patients before elective aortocoronary vein bypass graft operations. Compared with awake measurements, the mean arterial pressure (MAP) decreased 19 +/- 3 torr (mean +/- SE) and heart rate (HR) increased 9 +/- 3 bpm 1 minute after thiamylal-SCh. MAP was increased 39 +/- 4 torr and HR 20 +/- 3 bpm above awake levels in response to laryngoscopy and tracheal intubation. Blood pressure and HR returned spontaneously to near awake levels without additional anesthesia within 5 minutes of anesthetic induction. Stroke volume index was decreased significantly after tracheal intubation but cardiac index was not altered. The authors conclude that thiamylal-SCh followed by tracheal intubation is an acceptable anesthetic induction sequence for patients without evidence of left ventricular heart failure who require anesthesia for elective coronary artery revascularization.
在20例择期主动脉冠状动脉静脉搭桥手术患者中，测量了给予硫喷妥钠（4mg/kg）和琥珀酰胆碱（SCh）（2mg/kg）后，接着进行直接喉镜检查和气管插管后的循环反应。与清醒状态下测量值相比，硫喷妥钠-琥珀酰胆碱给药1分钟后平均动脉压（MAP）下降19±3托（均值±标准误），心率（HR）增加9±3次/分钟。因喉镜检查和气管插管，MAP比清醒时水平升高39±4托，HR升高20±3次/分钟。麻醉诱导后5分钟内，血压和心率在未追加麻醉的情况下自发恢复至接近清醒水平。气管插管后每搏量指数显著降低，但心脏指数未改变。作者得出结论，对于无左心室心力衰竭证据且需要择期冠状动脉血运重建麻醉的患者，硫喷妥钠-琥珀酰胆碱后气管插管是一种可接受的麻醉诱导顺序。
