Miletich D J, Ivankovich A D, Albrecht R F, Bonnet R F, Reimann C R
Anesth Analg. 1976 Mar-Apr;55(2):279-85. doi: 10.1213/00000539-197603000-00034.
The effects of doxapram on cerebral blood flow (CBF) and peripheral hemodynamics were evaluated in the goat after direct injection into the cerebral circulation and after peripheral IV administration. Doxapram injected centrally via the temporal artery, in doses too small to affect peripheral circulation, produced an immediate and prolonged decrease in CBF in both anesthetized and unanesthetized gohanges in blood CO2 concentration, since blood flow decreased immediately after injection and as reduction in CBF occurred in the absence of changes in blood CO2. Pheripheral IV administration of doxapram in clinical doses to anesthetized and unanesthetized goats produced a biphasic cardiovascular response. Cerebral blood flow, cardiac output, blood pressure, and heart rate decreased abruptly, but with the exception of CBF, these parameters returned to or exceeded preinjection values within 30 seconds. Cerebral blood flow slowly returned to preinjection values (within 10 minutes) and, in the case of unanesthetized animals and anesthetized animals ventilated with room air, rose substantially above preinjection levels, reaching a peak 20 minutes after injection. The latter observation is thought to be a compensatory reaction to the reduction in CBF; it was not evident in anesthetized animals ventilated with 100% O2.
在山羊经脑循环直接注射多沙普仑以及经外周静脉给药后，评估了多沙普仑对脑血流量（CBF）和外周血流动力学的影响。通过颞动脉向中枢注射小剂量多沙普仑，该剂量不足以影响外周循环，可使麻醉和未麻醉山羊的CBF立即且持续降低。CBF的降低并非由血液二氧化碳浓度变化所致，因为注射后血流量立即下降，且在血液二氧化碳无变化的情况下CBF也出现降低。向麻醉和未麻醉山羊外周静脉注射临床剂量的多沙普仑会产生双相心血管反应。脑血流量、心输出量、血压和心率会突然下降，但除CBF外，这些参数在30秒内恢复到或超过注射前值。脑血流量缓慢恢复到注射前值（10分钟内），对于未麻醉动物和用室内空气通气的麻醉动物，CBF在注射后20分钟达到峰值，显著高于注射前水平。后一观察结果被认为是对CBF降低的一种代偿反应；在用100%氧气通气的麻醉动物中未观察到这种现象。
