Ibrahim H N, Hostetter T H
Renal Division, University of Minnesota, Minneapolis 55455, USA.
J Am Soc Nephrol. 1998 Jan;9(1):72-6. doi: 10.1681/ASN.V9172.
The renin-angiotensin-aldosterone system participates in chronic progressive renal disease. The studies presented here assessed the importance of aldosterone in two different methods of reduced kidney mass in the rat, i.e., the infarction model (INF; uninephrectomy plus infarction of approximately two-thirds of the other kidney) and surgical excision or polectomy (POL; uninephrectomy plus surgical excision of both poles of the other kidney). Equivalent degrees of reduction in renal mass were confirmed by the similarity of serum creatinines 3 d after the ablative procedure. Measurements were made thereafter at 2 and 4 wk postablation. Systolic arterial pressure was greater with INF at both 2 and 4 wk. Proteinuria was also greater in the INF group at both time periods. The percentage of glomeruli with sclerosis measured at 4 wk tended to be greater in the INF group; however, this difference was not of statistical significance. At 2 wk, plasma renin activity and plasma aldosterone levels were lower in the POL group. The renin concentration in the scar region of the kidneys in the INF group was higher than in the kidney of the POL group. In conjunction with the lower plasma aldosterone, rats in the POL group had higher plasma potassium concentrations at 2 wk. In summary, higher aldosterone and plasma renin levels distinguish the INF model from the POL and likely contribute to the greater proteinuria and hypertension in the INF model.
肾素-血管紧张素-醛固酮系统参与慢性进行性肾病。本文所呈现的研究评估了醛固酮在大鼠两种不同的肾质量减少方法中的重要性，即梗死模型（INF；单侧肾切除加另一侧肾脏约三分之二梗死）和手术切除或极切除术（POL；单侧肾切除加另一侧肾脏两极的手术切除）。在切除手术后3天，通过血清肌酐的相似性证实了肾质量的等效减少程度。此后在切除术后2周和4周进行测量。在2周和4周时，INF组的收缩动脉压均更高。在这两个时间段，INF组的蛋白尿也更多。在4周时测量的硬化肾小球百分比在INF组中倾向于更高；然而，这种差异没有统计学意义。在2周时，POL组的血浆肾素活性和血浆醛固酮水平较低。INF组肾脏瘢痕区域的肾素浓度高于POL组的肾脏。与较低的血浆醛固酮相结合，POL组大鼠在2周时血浆钾浓度更高。总之，较高的醛固酮和血浆肾素水平将INF模型与POL模型区分开来，并可能导致INF模型中更大的蛋白尿和高血压。
