Pierce H I, McGuffin R G, Hillman R S
Arch Intern Med. 1976 Mar;136(3):283-9.
The incidence and characteristics of ring sideroblastic and megaloblastic changes in bone marrow were studied in chronically ill, malnourished alcoholics and well-nourished alcoholics without complicating medical illness. A clear correlation of blood alcohol level with changes in serum pyridoxal-5-phosphate (PLP) values or with the incidence of ring sideroblasts could not be demonstrated. The appearance of ring sideroblasts was associated with dietary restrictions of pyridoxine and noticeable folic-acid-deficient megaloblastosis. The majority of subjects with ring sideroblasts were from the chronic, malnourished alcoholic group; the number of sideroblasts correlated with severity of marrow magaloblastic change. While low serum PLP levels were characteristic of the chronically ill alcoholic with ring sideroblasts, equally low levels were detected in the absence of the marrow abnormality. Thus, a low serum PLP value alone is not a certain indication of the presence of marrow ring sideroblasts.
对患有慢性病、营养不良的酗酒者以及无并发疾病的营养良好的酗酒者的骨髓环形铁粒幼细胞和巨幼细胞改变的发生率及特征进行了研究。未发现血液酒精水平与血清磷酸吡哆醛（PLP）值变化或环形铁粒幼细胞发生率之间存在明显关联。环形铁粒幼细胞的出现与吡哆醇饮食限制以及明显的叶酸缺乏性巨幼细胞贫血有关。大多数有环形铁粒幼细胞的受试者来自慢性、营养不良的酗酒组；铁粒幼细胞数量与骨髓巨幼细胞改变的严重程度相关。虽然血清PLP水平低是患有环形铁粒幼细胞的慢性病酗酒者的特征，但在无骨髓异常的情况下也检测到了同样低的水平。因此，仅血清PLP值低并不能确定表明存在骨髓环形铁粒幼细胞。
