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1983年至1995年间在沙特阿拉伯分离出的O型口蹄疫病毒的分子分析

Molecular analysis of foot-and-mouth disease type O viruses isolated in Saudi Arabia between 1983 and 1995.

作者信息

Samuel A R, Knowles N J, Kitching R P, Hafez S M

机构信息

OIE/FAO World Reference Laboratory for Foot-and-Mouth Disease, Institute for Animal Health, Pirbright Laboratory, Surrey, UK.

出版信息

Epidemiol Infect. 1997 Dec;119(3):381-9. doi: 10.1017/s0950268897008285.

DOI:10.1017/s0950268897008285
PMID:9440443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2809012/
Abstract

Partial nucleotide sequence of the capsid polypeptide coding gene 1D (VP1) was determined for 68 serotype O foot-and-mouth disease viruses isolated between 1983 and 1995 from outbreaks occurring in Saudi Arabia. The sequences were compared with previously published sequences: 14 viruses of Middle Eastern origin (isolated between 1987 and 1991); and with four vaccine virus strain sequences, three originating from the Middle East (O1/Turkey/Manisa/69, O1/Sharquia/Egypt/72 and O1/Israel/2/85) and one from Europe (O1/BFS 1860/UK/67). The virus isolates from Saudi Arabia and the Middle East vaccine virus strains formed a related genetic group distinct from the European O1 virus. Within this large group 12 distinct genetic sublineages were observed.

摘要

测定了1983年至1995年间从沙特阿拉伯疫情中分离出的68株O型口蹄疫病毒衣壳多肽编码基因1D（VP1）的部分核苷酸序列。将这些序列与先前发表的序列进行了比较：14株中东起源的病毒（1987年至1991年间分离）；以及4株疫苗病毒株序列，其中3株起源于中东（O1/土耳其/马尼萨/69、O1/沙基亚/埃及/72和O1/以色列/2/85），1株来自欧洲（O1/BFS 1860/英国/67）。来自沙特阿拉伯的病毒分离株和中东疫苗病毒株形成了一个与欧洲O1病毒不同的相关遗传群体。在这个大群体中观察到12个不同的遗传亚系。

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