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1
Construction and characterization of a Helicobacter pylori clpB mutant and role of the gene in the stress response.幽门螺杆菌clpB突变体的构建与鉴定及其基因在应激反应中的作用
J Bacteriol. 1998 Jan;180(2):426-9. doi: 10.1128/JB.180.2.426-429.1998.
2
The ClpB protein from Campylobacter jejuni: molecular characterization of the encoding gene and antigenicity of the recombinant protein.空肠弯曲杆菌的ClpB蛋白：编码基因的分子特征及重组蛋白的抗原性
Gene. 1999 Apr 1;230(1):61-7. doi: 10.1016/s0378-1119(99)00054-2.
3
Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses.猪布鲁氏菌clpB和clpAB突变体的特性及基因在应激反应中的作用。
J Bacteriol. 2001 Apr;183(8):2677-81. doi: 10.1128/JB.183.8.2677-2681.2001.
4
The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulon.白色链霉菌G的ClpB ATP酶属于HspR热休克调节子。
Mol Microbiol. 1999 Jan;31(2):521-32. doi: 10.1046/j.1365-2958.1999.01193.x.
5
Helicobacter pylori hspA-hspB heat-shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity.幽门螺杆菌hspA-hspB热休克基因簇：核苷酸序列、表达、推定功能及免疫原性。
Mol Microbiol. 1994 Dec;14(5):959-74. doi: 10.1111/j.1365-2958.1994.tb01331.x.
6
The clp (CS31A) operon is negatively controlled by Lrp, ClpB, and L-alanine at the transcriptional level.clp（CS31A）操纵子在转录水平上受到Lrp、ClpB和L-丙氨酸的负调控。
Mol Microbiol. 1996 Jul;21(2):281-92. doi: 10.1046/j.1365-2958.1996.00651.x.
7
Disruption and analysis of the clpB, clpC, and clpE genes in Lactococcus lactis: ClpE, a new Clp family in gram-positive bacteria.乳酸乳球菌中clpB、clpC和clpE基因的破坏与分析：ClpE，革兰氏阳性菌中的一个新的Clp家族。
J Bacteriol. 1999 Apr;181(7):2075-83. doi: 10.1128/JB.181.7.2075-2083.1999.
8
ClpB is the Escherichia coli heat shock protein F84.1.ClpB是大肠杆菌热休克蛋白F84.1。
J Bacteriol. 1991 Jul;173(14):4254-62. doi: 10.1128/jb.173.14.4254-4262.1991.
9
ClpB in a cyanobacterium: predicted structure, phylogenetic relationships, and regulation by light and temperature.蓝藻中的ClpB：预测结构、系统发育关系以及光和温度的调控
J Bacteriol. 1998 Oct;180(19):5173-82. doi: 10.1128/JB.180.19.5173-5182.1998.
10
The heat shock protein ClpB mediates the development of thermotolerance in the cyanobacterium Synechococcus sp. strain PCC 7942.热休克蛋白ClpB介导了聚球藻属蓝细菌PCC 7942菌株耐热性的形成。
J Bacteriol. 1996 Aug;178(16):4839-46. doi: 10.1128/jb.178.16.4839-4846.1996.

引用本文的文献

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The Role of ClpB in Bacterial Stress Responses and Virulence.ClpB在细菌应激反应和毒力中的作用。
Front Mol Biosci. 2021 Apr 22;8:668910. doi: 10.3389/fmolb.2021.668910. eCollection 2021.
2
Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions.幽门螺杆菌丝氨酸蛋白酶 HtrA 的伴侣活性作为应激条件下的关键生存因素。
Cell Commun Signal. 2019 Dec 3;17(1):161. doi: 10.1186/s12964-019-0481-9.
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Protein aggregation in bacteria.细菌中的蛋白质聚集。
FEMS Microbiol Rev. 2020 Jan 1;44(1):54-72. doi: 10.1093/femsre/fuz026.
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The amino-terminal domain of ClpB protein plays a crucial role in its substrate disaggregation activity.ClpB蛋白的氨基末端结构域在其底物解聚活性中起关键作用。
FEBS Open Bio. 2018 Sep 15;8(10):1669-1690. doi: 10.1002/2211-5463.12509. eCollection 2018 Oct.
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Comparative roles of clpA and clpB in the survival of S. Typhimurium under stress and virulence in poultry.clpA 和 clpB 在鼠伤寒沙门氏菌应激和禽类致病中的生存比较作用。
Sci Rep. 2018 Mar 14;8(1):4481. doi: 10.1038/s41598-018-22670-6.
6
IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.在第二次肺土拉弗朗西斯菌活疫苗株感染期间的存活需要IFN-γ，而非IL-17A。
Vaccine. 2014 Jun 17;32(29):3595-603. doi: 10.1016/j.vaccine.2014.05.013. Epub 2014 May 14.
7
Characterization of monospecies biofilm formation by Helicobacter pylori.幽门螺杆菌单菌种生物膜形成的特性分析
J Bacteriol. 2004 May;186(10):3124-32. doi: 10.1128/JB.186.10.3124-3132.2004.
8
clpB, a novel member of the Listeria monocytogenes CtsR regulon, is involved in virulence but not in general stress tolerance.clpB是单核细胞增生李斯特菌CtsR调控子的一个新成员，参与毒力但不参与一般应激耐受。
J Bacteriol. 2004 Feb;186(4):1165-74. doi: 10.1128/JB.186.4.1165-1174.2004.
9
Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses.猪布鲁氏菌clpB和clpAB突变体的特性及基因在应激反应中的作用。
J Bacteriol. 2001 Apr;183(8):2677-81. doi: 10.1128/JB.183.8.2677-2681.2001.
10
The Escherichia coli heat shock protein ClpB restores acquired thermotolerance to a cyanobacterial clpB deletion mutant.大肠杆菌热休克蛋白ClpB可恢复蓝藻clpB缺失突变体的获得性耐热性。
Cell Stress Chaperones. 2000 Jul;5(3):255-64. doi: 10.1379/1466-1268(2000)005<0255:techsp>2.0.co;2.

本文引用的文献

1
The complete genome sequence of the gastric pathogen Helicobacter pylori.胃病原体幽门螺杆菌的全基因组序列。
Nature. 1997 Aug 7;388(6642):539-47. doi: 10.1038/41483.
2
Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain.幽门螺杆菌过氧化氢酶的克隆、遗传特征分析及过氧化氢酶缺陷突变株的构建
J Bacteriol. 1996 Dec;178(23):6960-7. doi: 10.1128/jb.178.23.6960-6967.1996.
3
Identification of a ClpC ATPase required for stress tolerance and in vivo survival of Listeria monocytogenes.鉴定一种对单核细胞增生李斯特菌的应激耐受性和体内存活至关重要的ClpC ATP酶。
Mol Microbiol. 1996 Sep;21(5):977-87. doi: 10.1046/j.1365-2958.1996.641432.x.
4
Construction and characterization of a Yersinia enterocolitica O:8 high-temperature requirement (htrA) isogenic mutant.小肠结肠炎耶尔森菌O:8高温需求（htrA）基因缺失突变株的构建与鉴定
Infect Immun. 1996 Jun;64(6):2088-94. doi: 10.1128/iai.64.6.2088-2094.1996.
5
Aflagellated mutants of Helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesis.通过转座子穿梭诱变对自然感受态菌株进行遗传转化而产生的幽门螺杆菌无鞭毛突变体。
Mol Microbiol. 1993 May;8(4):753-60. doi: 10.1111/j.1365-2958.1993.tb01618.x.
6
Stress induction of clpC in Bacillus subtilis and its involvement in stress tolerance.枯草芽孢杆菌中clpC的应激诱导及其在应激耐受性中的作用。
J Bacteriol. 1994 Jun;176(11):3360-7. doi: 10.1128/jb.176.11.3360-3367.1994.
7
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins.热休克蛋白在应激耐受中的作用：受损蛋白质的降解与再激活。
Annu Rev Genet. 1993;27:437-96. doi: 10.1146/annurev.ge.27.120193.002253.
8
A PCR-based strategy for the rapid construction of defined bacterial deletion mutants.一种基于聚合酶链反应的快速构建特定细菌缺失突变体的策略。
Biotechniques. 1994 Jun;16(6):994-6.
9
Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant.流产布鲁氏菌高温需求A（htrA）缺失突变体的鉴定与基因互补
Infect Immun. 1994 Oct;62(10):4135-9. doi: 10.1128/iai.62.10.4135-4139.1994.
10
Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production.幽门螺杆菌和鼬源螺杆菌鞭毛钩产生缺陷的非运动性突变体。
Mol Microbiol. 1994 Nov;14(4):691-703. doi: 10.1111/j.1365-2958.1994.tb01307.x.

幽门螺杆菌clpB突变体的构建与鉴定及其基因在应激反应中的作用

Construction and characterization of a Helicobacter pylori clpB mutant and role of the gene in the stress response.

作者信息

Allan E, Mullany P, Tabaqchali S

机构信息

Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, West Smithfield, United Kingdom.

出版信息

J Bacteriol. 1998 Jan;180(2):426-9. doi: 10.1128/JB.180.2.426-429.1998.

DOI:10.1128/JB.180.2.426-429.1998
PMID:9440536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC106902/
Abstract

Antiserum raised against whole Helicobacter pylori cells identified a novel 94-kDa antigen. The nucleotide sequence of the gene encoding the 94-kDa antigen was determined, and analysis of the deduced amino acid sequence revealed structural features typical of the ClpB ATPase family of stress response proteins. An isogenic H. pylori clpB mutant showed increased sensitivity to high-temperature stress, indicating that the clpB gene product functions as a stress response protein in H. pylori.

摘要

针对幽门螺杆菌全菌产生的抗血清鉴定出一种新的94 kDa抗原。测定了编码该94 kDa抗原的基因的核苷酸序列，对推导的氨基酸序列的分析揭示了应激反应蛋白的ClpB ATP酶家族典型的结构特征。一株同源的幽门螺杆菌clpB突变体对高温应激的敏感性增加，表明clpB基因产物在幽门螺杆菌中作为一种应激反应蛋白发挥作用。