Leibovitch I, Foster R S, Kopecky K K, Albers P, Ulbright T M, Donohue J P
Department of Urology, Indiana University School of Medicine, Indianapolis 46202, USA.
J Clin Oncol. 1998 Jan;16(1):261-8. doi: 10.1200/JCO.1998.16.1.261.
To evaluate previously determined predictors of metastasis in low-stage testis cancer in a consecutive group of clinical stage A patients.
Ninety-one consecutive clinical stage A nonseminomatous germ cell tumor (NSGCT) patients who underwent primary nerve-sparing retroperitoneal lymph node dissection (NSRPLND) had orchiectomy specimens and computed tomographic (CT) scans evaluated blindly in a quantitative fashion. These scores were then correlated with pathologic stage using previously determined paradigms.
Using volume of embryonal carcinoma in the orchiectomy specimen, lymph node diameters in the primary landing zones and MIB-1 staining of the orchiectomy specimen, 41 patients were classified as low risk for metastasis. Forty of these 41 had pathologic stage A disease at RPLND.
These parameters can identify a low-risk group of patients for metastasis who can be rationally offered surveillance.
在一组连续的临床分期为A期的患者中，评估先前确定的低分期睾丸癌转移预测指标。
91例连续的临床分期为A期的非精原细胞性生殖细胞肿瘤（NSGCT）患者接受了保留神经的腹膜后淋巴结清扫术（NSRPLND），对其睾丸切除标本和计算机断层扫描（CT）进行了盲法定量评估。然后使用先前确定的范式将这些评分与病理分期相关联。
根据睾丸切除标本中胚胎癌的体积、主要着陆区的淋巴结直径以及睾丸切除标本的MIB-1染色，41例患者被归类为转移低风险。这41例患者中有40例在腹膜后淋巴结清扫术时病理分期为A期。
这些参数可以识别出转移低风险的患者群体，可合理地对其进行监测。
