Vermylen P, Berghmans T, Roufosse C, Pierard P, Ninane V, Sculier J P
Service de Médecine, Institut Jules Bordet, Bruxelles.
Rev Med Brux. 1997 Oct;18(5):347-52.
Lung cancer is the cancer with the largest mortality in Belgium. Nowadays, the most potent risk factor for lung cancer, tobacco smoking, is increasing, principally in teenagers. It is therefore necessary to intervene more efficiently in the natural history of the disease. This aim can be achieve by the early detection and the local treatment of small size lung cancer and in situ carcinoma. Interestingly, pulmonary preneoplastic lung lesions have been identified and characterized in the central airways as well as in the peripheral lung parenchyma. These preneoplastic lesions can evolve to invasive cancer or regress after tobacco smoking cessation or chemoprevention treatment. A new autofluorescence based endoscopy technique is described, that allows to detect preneoplastic pulmonary lesions and radio-occult lung cancer. These small sized lesions can be cured with endoscopic local treatment such as photodynamic therapy.
肺癌是比利时死亡率最高的癌症。如今，肺癌最主要的风险因素——吸烟，正在增加，主要是在青少年群体中。因此，有必要更有效地干预该疾病的自然病程。这一目标可以通过早期发现和对小尺寸肺癌及原位癌进行局部治疗来实现。有趣的是，在中央气道以及外周肺实质中已鉴定并表征了肺的癌前病变。这些癌前病变可发展为浸润性癌，或在戒烟或进行化学预防治疗后消退。本文描述了一种基于自体荧光的新型内镜技术，该技术能够检测癌前肺部病变和隐匿性肺癌。这些小尺寸病变可通过光动力疗法等内镜局部治疗治愈。
