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新生儿胆汁淤积综合征:胆囊超声检查的价值

[Cholestasis syndrome in newborn infants: value of gallbladder ultrasound].

作者信息

Wandl-Vergesslich K, Strasser R, Gulesserian T, Youssefzadeh S, Radner M, Weninger M

机构信息

Abteilung Allgemeine Pädiatrie, Universitätsklinik für Kinder und Jugendheilkunde Wien.

出版信息

Ultraschall Med. 1997 Oct;18(5):205-8. doi: 10.1055/s-2007-1000426.

DOI:10.1055/s-2007-1000426
PMID:9441387
Abstract

PURPOSE

Evaluation of sonography in the assessment of changes of the biliary system of newborn infants receiving total parenteral nutrition.

PATIENTS AND METHODS

In 20 premature infants on mechanical ventilation, the influence of two different amino acid solutions (Vaminolac, Paedamin) in the development of neonatal cholestasis was analysed. The patients were randomised in two groups. Group 1 (n = 11) received Paedamin, group 2 (n = 9) received Vaminolac.

RESULTS

There was no statistically significant influence of the amino acid solution on the development of cholestasis. However, the majority of the children with cholestasis (8 of 11) presented with sepsis.

CONCLUSION

Bacterial infections seem to be closely related to the development of cholestasis. Sludge formation within the bile ducts represents a sensitive sonographic parameter for the diagnosis and follow-up of cholestasis secondary to total parenteral nutrition.

摘要

目的

评估超声检查在接受全胃肠外营养的新生儿胆道系统变化评估中的作用。

患者与方法

对20例接受机械通气的早产儿,分析两种不同氨基酸溶液(凡命、小儿氨基酸)对新生儿胆汁淤积症发生发展的影响。将患者随机分为两组。第1组(n = 11)接受小儿氨基酸,第2组(n = 9)接受凡命。

结果

氨基酸溶液对胆汁淤积症的发生发展无统计学显著影响。然而,大多数胆汁淤积症患儿(11例中的8例)伴有败血症。

结论

细菌感染似乎与胆汁淤积症的发生密切相关。胆管内形成胆泥是全胃肠外营养继发胆汁淤积症诊断及随访的一个敏感超声参数。

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1
[Cholestasis syndrome in newborn infants: value of gallbladder ultrasound].新生儿胆汁淤积综合征:胆囊超声检查的价值
Ultraschall Med. 1997 Oct;18(5):205-8. doi: 10.1055/s-2007-1000426.
2
Cholestatic tendencies in premature infants on and off parenteral nutrition.
Pediatrics. 1978 Dec;62(6):984-9.
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Rapid intravenous administration of amino acids prevents biliary sludge induced by total parenteral nutrition in humans.快速静脉输注氨基酸可预防全胃肠外营养引起的人体胆泥形成。
J Hepatobiliary Pancreat Surg. 2000;7(5):504-9. doi: 10.1007/s005340070022.
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Sonographic diagnosis of biliary atresia in pediatric patients using the "triangular cord" sign versus gallbladder length and contraction.使用“三角索带”征与胆囊长度及收缩情况对小儿患者进行胆道闭锁的超声诊断
AJR Am J Roentgenol. 2003 Nov;181(5):1387-90. doi: 10.2214/ajr.181.5.1811387.
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[A new amino acid solution for parenteral nutrition of premature infants, newborn infants and infants].[一种用于早产儿、新生儿及婴儿肠外营养的新型氨基酸溶液]
Infusionstherapie. 1990 Feb;17(1):40-6.
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[Amino acid requirements of premature and newborn infants and young infants in enteral and parenteral nutrition. A critical presentation of the organized methodology and comparative evaluation of amino acid requirements].[早产儿、新生儿及小婴儿肠内和肠外营养中的氨基酸需求。氨基酸需求的组织方法和比较评估的关键呈现]
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Hyperalimentation-induced cholestasis. Increased incidence and severity in premature infants.
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[Congenital extrahepatic biliary atresia as a cause of cholestasis in newborns and infants].[先天性肝外胆管闭锁作为新生儿和婴儿胆汁淤积的原因]
Med Wieku Rozwoj. 2006 Apr-Jun;10(2):395-406.
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Surgical treatment of intractable cholestasis associated with total parenteral nutrition in premature infants.早产儿全胃肠外营养相关顽固性胆汁淤积的外科治疗
J Pediatr Surg. 1993 May;28(5):716-9. doi: 10.1016/0022-3468(93)90040-r.
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Resolution of intractable cholestasis associated with total parenteral nutrition following biliary irrigation.经胆道冲洗后,与全胃肠外营养相关的顽固性胆汁淤积得到缓解。
J Pediatr Surg. 1985 Dec;20(6):772-4. doi: 10.1016/s0022-3468(85)80042-7.