Voiculescu A, Kutkuhn B, Rösen P, Grabensee B
Klinik für Nephrologie und Rheumatologie, Heinrich-Heine-Universität Düsseldorf.
Wien Klin Wochenschr. 1997 Oct 17;109(19):758-66.
Non insulin dependent diabetes mellitus (NIDDM) and obesity are defined as classical insulin resistant states. Essential hypertension is now also considered to be an insulin resistant state, even in absence of NIDDM or obesity, as shown in epidemiological, clinical and experimental studies. Neither the underlying mechanism nor a direct causality between the two phenomena has been detected as yet, but different hypotheses have been postulated where, on the one hand, insulin resistance and hypertension are considered to be causally related and, on the other hand, they are considered to be parallel phenomena due to genetic and acquired factors. The clarification of the connection between hypertension and insulin resistance seems to be of great clinical importance, since they are both independent risk factors for cardiovascular disease and mortality from cardiovascular complications. This paper gives an overview of the results of recent research on the possible underlying pathogenetic mechanisms linking hypertension and insulin resistance.
非胰岛素依赖型糖尿病（NIDDM）和肥胖被定义为典型的胰岛素抵抗状态。目前，原发性高血压也被认为是一种胰岛素抵抗状态，即使在没有NIDDM或肥胖的情况下也是如此，流行病学、临床和实验研究均已表明这一点。目前尚未发现这两种现象之间的潜在机制或直接因果关系，但已经提出了不同的假设，一方面，胰岛素抵抗和高血压被认为存在因果关系，另一方面，由于遗传和后天因素，它们被认为是平行现象。阐明高血压与胰岛素抵抗之间的联系似乎具有重要的临床意义，因为它们都是心血管疾病和心血管并发症致死的独立危险因素。本文概述了近期关于高血压与胰岛素抵抗之间可能的潜在发病机制的研究结果。
