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蛋白激酶C（PKC）在恶性胶质瘤的发生发展及增殖中的作用，以及PKC抑制作为一种新型抗胶质瘤治疗方法的应用。

The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy.

作者信息

Bredel M, Pollack I F

机构信息

Department of Neurosurgery, University of Pittsburgh School of Medicine, PA, USA.

出版信息

Acta Neurochir (Wien). 1997;139(11):1000-13. doi: 10.1007/BF01411552.

DOI:10.1007/BF01411552
PMID:9442212
Abstract

The present article reviews the role of the second messenger enzyme protein kinase C (PKC) in the growth regulation of high-grade gliomas, and evaluates the efficacy of therapeutic strategies directed against PKC for blocking the proliferation of these malignancies in in vitro and in vivo models. The translation of such strategies to the treatment of patients with malignant gliomas may provide a novel approach for improving the otherwise grim outlook associated with these neoplasms.

摘要

本文综述了第二信使酶蛋白激酶C（PKC）在高级别胶质瘤生长调控中的作用，并评估了针对PKC的治疗策略在体外和体内模型中阻断这些恶性肿瘤增殖的疗效。将此类策略转化用于治疗恶性胶质瘤患者可能为改善这些肿瘤通常严峻的预后提供一种新方法。

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