Sauter P, Matthias P
Friedrich Miescher Institute, Basel, Switzerland.
Immunobiology. 1997 Dec;198(1-3):207-16. doi: 10.1016/S0171-2985(97)80041-1.
The transcriptional coactivator variously known as OBF-1, OCA-B or Bob-1 has previously been shown to be expressed in a highly B cell-specific manner. Here we show that expression of the OBF-1 gene is also observed in several T cell lines as well as in primary T cells following activation. This suggests that this coactivator may also be involved in transcriptional control in T lymphocytes. In addition we show that several potential T cell-specific target genes which have octamer sites in their regulatory regions, such as the genes coding for interleukin-2, -3 and -4, are still properly regulated in T cells isolated from OBF-1-/- mice.
转录共激活因子，有多种名称，如OBF-1、OCA-B或Bob-1，先前已被证明以高度B细胞特异性的方式表达。在此我们表明，在几种T细胞系以及激活后的原代T细胞中也观察到OBF-1基因的表达。这表明该共激活因子可能也参与T淋巴细胞的转录调控。此外，我们还表明，在从OBF-1基因敲除小鼠分离出的T细胞中，几个在其调控区域具有八聚体位点的潜在T细胞特异性靶基因，如编码白细胞介素-2、-3和-4的基因，仍受到正常调控。
