Department of Oto-Rhino-Larnygology, Ulm University Medical Center, Ulm, Germany.
Core Facility Immune Monitoring, Ulm University, Ulm, Germany.
Adv Exp Med Biol. 2024;1459:53-77. doi: 10.1007/978-3-031-62731-6_3.
BOB.1/OBF.1 is a transcriptional coactivator involved in octamer-dependent transcription. Thereby, BOB.1/OBF.1 is involved in the transcriptional regulation of genes important for lymphocyte physiology. BOB.1/OBF.1-deficient mice reveal multiple B- and T-cell developmental defects. The most prominent defect of these mice is the complete absence of germinal centers (GCs) resulting in severely impaired T-cell-dependent immune responses. In humans, BOB.1/OBF.1 is associated with several autoimmune and inflammatory diseases but also linked to liquid and solid tumors. Although its role for B-cell development is relatively well understood, its exact role for the GC reaction and T-cell biology has long been unclear. Here, the contribution of BOB.1/OBF.1 for B-cell maturation is summarized, and recent findings regarding its function in GC B- as well as in various T-cell populations are discussed. Finally, a detailed perspective on how BOB.1/OBF.1 contributes to different pathologies is provided.
BOB.1/OBF.1 是一种转录共激活因子，参与八聚体依赖性转录。因此，BOB.1/OBF.1 参与了对淋巴细胞生理学重要基因的转录调控。BOB.1/OBF.1 缺陷小鼠显示出多种 B 和 T 细胞发育缺陷。这些小鼠最显著的缺陷是完全缺乏生发中心（GC），导致 T 细胞依赖性免疫反应严重受损。在人类中，BOB.1/OBF.1 与多种自身免疫和炎症性疾病有关，但也与液体和实体肿瘤有关。尽管其在 B 细胞发育中的作用相对较好理解，但它在 GC B 细胞以及各种 T 细胞群体中的确切功能长期以来一直不清楚。本文总结了 BOB.1/OBF.1 对 B 细胞成熟的贡献，并讨论了最近关于其在 GC B 细胞以及各种 T 细胞群体中的功能的发现。最后，提供了对 BOB.1/OBF.1 如何导致不同病理的详细观点。
