Smith A M, Klugman K P
Department of Medical Microbiology, South African Institute for Medical Research, Johannesburg, South Africa.
Microb Drug Resist. 1997 Winter;3(4):385-9. doi: 10.1089/mdr.1997.3.385.
The worldwide spread of antibiotic-resistant pneumococcal clones is cause for concern. In South Africa, penicillin-resistant pneumococci are mostly associated with serogroups 6 and 19, therefore, we have analyzed the clonal relationships between resistant isolates of these two serogroups. DNA fingerprinting of penicillin-binding protein genes and arbitrarily-primed PCR, have identified two penicillin-resistant pneumococcal clones of serotype 19A and serotype 6B, and a third multi-resistant serotype 19A clone, of which all three clones are predominant within South Africa's penicillin-resistant pneumococcal population. These clones are represented by strains isolated from hospitals that are widely separated in South Africa. Further studies are required to establish whether these clones have expanded in the rest of Africa or spread to other continents.
耐抗生素肺炎球菌克隆在全球范围内的传播令人担忧。在南非，耐青霉素肺炎球菌大多与血清群6和19相关，因此，我们分析了这两个血清群耐药分离株之间的克隆关系。青霉素结合蛋白基因的DNA指纹图谱和随机引物PCR已鉴定出两个19A血清型和6B血清型的耐青霉素肺炎球菌克隆，以及第三个多重耐药的19A血清型克隆，这三个克隆在南非耐青霉素肺炎球菌群体中均占主导地位。这些克隆由从南非各地相距甚远的医院分离出的菌株代表。需要进一步研究以确定这些克隆是否已在非洲其他地区扩散或传播到其他大陆。
