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清除对吸入氧化亚氮和氧气镇静的受试者精神运动和认知功能的影响。

Effect of scavenging on the psychomotor and cognitive function of subjects sedated with nitrous oxide and oxygen inhalation.

作者信息

Primosch R, McLellan M, Jerrell G, Venezie R

机构信息

Department of Pediatric Dentistry, College of Dentistry, University of Florida, Gainesville, USA.

出版信息

Pediatr Dent. 1997 Nov-Dec;19(8):480-3.

PMID:9442542
Abstract

Maximizing scavenger effectiveness using a 45 L/min evacuation rate as recommended by the National Institute of Occupational Safety and Health (NIOSH) may alter the sedation level of the dental patient. The purpose of this pilot study was to determine if scavenging at the recommended NIOSH evacuation rate reduced psychomotor and cognitive impairment as a result of inhaling nitrous oxide. Computer-administered neurobehavioral tests of human psychomotor and cognitive function previously established in controlled trials to be sensitive to nitrous oxide inhalation were employed in this blind, randomized, crossover study of 30 healthy adult subjects. The results indicated that scavenging produced statistically significant improvement in finger-tapping speed, symbol/digit coding speed, and recall accuracy. Hand/eye coordination was not improved significantly by scavenging. Enhancement of psychomotor skills and cognitive functioning was interpreted as an undesirable side effect of scavenging that could potentially influence dental patient anxiety management when using nitrous oxide inhalation. The results of this pilot study suggested that scavenger operation under the conditions tested could reduce the level of psychosedation achieved with nitrous oxide inhalation.

摘要

按照美国国家职业安全与健康研究所(NIOSH)的建议,以45升/分钟的抽气速率来最大化清除器的效率,可能会改变牙科患者的镇静水平。这项初步研究的目的是确定按照NIOSH建议的抽气速率进行清除,是否能减少因吸入氧化亚氮而导致的精神运动和认知障碍。在这项针对30名健康成年受试者的盲法、随机、交叉研究中,采用了先前在对照试验中确定对吸入氧化亚氮敏感的计算机管理的人类精神运动和认知功能神经行为测试。结果表明,清除在手指敲击速度、符号/数字编码速度和回忆准确性方面产生了具有统计学意义的改善。清除对手眼协调能力没有显著改善。精神运动技能和认知功能的增强被解释为清除的不良副作用,在使用氧化亚氮吸入时可能会潜在地影响牙科患者的焦虑管理。这项初步研究的结果表明,在所测试的条件下,清除器的运行可能会降低吸入氧化亚氮所达到的精神镇静水平。

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