Morgan D O
Department of Physiology, University of California, San Francisco 94143-0444, USA.
Annu Rev Cell Dev Biol. 1997;13:261-91. doi: 10.1146/annurev.cellbio.13.1.261.
Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.
细胞周期蛋白依赖性激酶（Cdks）在真核细胞分裂周期的调控中发挥着既定作用，并且也与基因转录及其他过程的控制有关。Cdk活性受一个由调节亚基和磷酸化事件组成的复杂网络支配，最近的晶体学研究揭示了这些事件对Cdk构象的确切影响。在细胞中，这些调节机制产生一系列相互关联的Cdk振荡器，从而触发细胞分裂事件。
