Flint J, Shenk T
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
Annu Rev Genet. 1997;31:177-212. doi: 10.1146/annurev.genet.31.1.177.
Many viruses utilize the cellular transcription apparatus to express their genomes, and they encode transcriptional regulatory proteins that modulate the process. Here we review the current understanding of three viral regulatory proteins. The adenovirus E1A protein acts within the nucleus to regulate transcription through its ability to bind to other proteins. The herpes simplex type 1 virus VP16 protein acts within the nucleus to control transcription by binding to DNA in conjunction with cellular proteins. The human T-cell leukemia virus Tax protein influences transcription through interactions with cellular proteins in the nucleus as well as the cytoplasm.
许多病毒利用细胞转录装置来表达其基因组，并且它们编码调节这一过程的转录调节蛋白。在此，我们综述对三种病毒调节蛋白的当前认识。腺病毒E1A蛋白在细胞核内通过其与其他蛋白结合的能力来调节转录。单纯疱疹病毒1型VP16蛋白在细胞核内通过与细胞蛋白结合于DNA来控制转录。人类T细胞白血病病毒Tax蛋白通过与细胞核以及细胞质中的细胞蛋白相互作用来影响转录。
