de Cuevas M, Lilly M A, Spradling A C
Howard Hughes Medical Institute/Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.
Annu Rev Genet. 1997;31:405-28. doi: 10.1146/annurev.genet.31.1.405.
In a wide variety of organisms, gametes develop within clusters of interconnected germline cells called cysts. Four major principles guide the construction of most cysts: synchronous division, a maximally branched pattern of interconnection between cells, specific changes in cyst geometry, and cyst polarization. The fusome is a germline-specific organelle that is associated with cyst formation in many insects and is likely to play an essential role in these processes. This review examines the cellular and molecular processes that underlie fusome formation and cyst initiation, construction, and polarization in Drosophila melanogaster. The studies described here highlight the importance of cyst formation to the subsequent development of functional gametes.
在各种各样的生物体中，配子在称为囊肿的相互连接的生殖系细胞簇中发育。四个主要原则指导着大多数囊肿的构建：同步分裂、细胞间最大程度的分支连接模式、囊肿几何形状的特定变化以及囊肿极化。纺锤体是一种生殖系特异性细胞器，与许多昆虫的囊肿形成有关，并且可能在这些过程中发挥重要作用。本综述研究了黑腹果蝇中纺锤体形成以及囊肿起始、构建和极化的细胞和分子过程。这里描述的研究突出了囊肿形成对功能性配子后续发育的重要性。
