丙戊酸治疗的癫痫儿童肉碱代谢的改变。
Alterations in the carnitine metabolism in epileptic children treated with valproic acid.
作者信息
Chung S, Choi J, Hyun T, Rha Y, Bae C
机构信息
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
出版信息
J Korean Med Sci. 1997 Dec;12(6):553-8. doi: 10.3346/jkms.1997.12.6.553.
Serum concentrations of total carnitine, free carnitine and acylcarnitine were measured in forty-one epileptic patients treated with valproic acid (VPA). Among them, 14 patients were on VPA monotherapy and 27 were on VPA polytherapy. Forty-one age and sex matched healthy normal controls were also evaluated for carnitine metabolism. The mean total and free carnitine were significantly lower in both the VPA monotherapy and polytherapy groups compared with the controls. However, there were no significant differences in concentrations of carnitine between the VPA polytherapy and VPA monotherapy groups. Patients treated with VPA polytherapy had lower carnitine than those treated with VPA monotherapy. An inverse correlation was found between serum concentrations of carnitine and duration of treatment in patients treated with VPA. However, there was no significant correlations between serum concentrations of carnitine and those of VPA. Also, correlation between serum concentrations of carnitine and the activities of serum GOT and GPT was not significant. After L-carnitine supplementation in eleven patients with hypocarnitinemia, the concentrations of carnitine were significantly increased.
对41例接受丙戊酸（VPA）治疗的癫痫患者测定了血清总肉碱、游离肉碱和酰基肉碱的浓度。其中，14例患者接受VPA单药治疗，27例患者接受VPA联合治疗。还对41名年龄和性别匹配的健康正常对照者的肉碱代谢进行了评估。与对照组相比，VPA单药治疗组和联合治疗组的平均总肉碱和游离肉碱均显著降低。然而，VPA联合治疗组和VPA单药治疗组之间的肉碱浓度没有显著差异。接受VPA联合治疗的患者的肉碱水平低于接受VPA单药治疗的患者。在接受VPA治疗的患者中，发现血清肉碱浓度与治疗持续时间呈负相关。然而，血清肉碱浓度与VPA浓度之间没有显著相关性。此外，血清肉碱浓度与血清谷草转氨酶（GOT）和谷丙转氨酶（GPT）活性之间的相关性也不显著。11例低肉碱血症患者补充左旋肉碱后，肉碱浓度显著升高。
Zotero 插件