Melberg A, Holme E, Oldfors A, Lundberg P O
Department of Neurology, Uppsala University Hospital, Sweden.
Neurology. 1998 Jan;50(1):299-300. doi: 10.1212/wnl.50.1.299.
Multiple mtDNA deletions have been reported to be a cause of inherited recurrent myoglobinuria. We report a 57-year-old man with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions who developed acute rhabdomyolysis provoked by alcohol. A repeated alcohol intake resulted in a 57-fold increase in serum myoglobin. Patients with mitochondrial myopathy and multiple mtDNA deletions, regardless of associated phenotype and mode of inheritance, may develop rhabdomyolysis.
据报道，多个线粒体DNA缺失是遗传性复发性肌红蛋白尿的一个病因。我们报告了一名57岁男性，患有常染色体显性进行性眼外肌麻痹和多个线粒体DNA缺失，他因酒精引发了急性横纹肌溶解症。反复摄入酒精导致血清肌红蛋白升高了57倍。患有线粒体肌病和多个线粒体DNA缺失的患者，无论其相关表型和遗传方式如何，都可能发生横纹肌溶解症。
