De Paermentier F, Lowther S, Crompton M R, Katona C L, Horton R W
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK.
J Psychopharmacol. 1997;11(4):295-9. doi: 10.1177/026988119701100403.
We have measured beta-adrenoceptor binding in pineal glands obtained at post mortem from suicides with a firm retrospective diagnosis of depression, and from age and gender-matched controls. In both antidepressant-free and antidepressant-treated suicides there were no significant differences in the number or affinity of beta-adrenoceptors compared to controls. Within the total group of subjects we found no variation in beta-adrenoceptor binding in relation to time of death or season of death. There was a significant negative correlation between the number of beta-adrenoceptors and age in controls, but not in suicides. These results suggest that pineal beta-adrenoceptors are not altered either in depression or as a result of antidepressant treatment.
我们已对死后取自经确诊为抑郁症的自杀者以及年龄和性别匹配的对照组的松果体中的β-肾上腺素能受体结合情况进行了测量。与对照组相比，在未服用抗抑郁药和服用抗抑郁药治疗的自杀者中，β-肾上腺素能受体的数量或亲和力均无显著差异。在所有受试者中，我们发现β-肾上腺素能受体结合情况与死亡时间或死亡季节无关。对照组中β-肾上腺素能受体数量与年龄之间存在显著负相关，但自杀者中不存在这种相关性。这些结果表明，松果体β-肾上腺素能受体在抑郁症中或抗抑郁药治疗后均未发生改变。
