De Paermentier F, Cheetham S C, Crompton M R, Katona C L, Horton R W
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, U.K.
Brain Res. 1990 Aug 13;525(1):71-7. doi: 10.1016/0006-8993(90)91321-7.
beta-Adrenoceptor binding sites were quantitated by saturation binding of [3H]CGP 12177 in 9 brain regions from 21 suicide victims, with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. In depressed suicides the number of total beta-adrenoceptors was significantly lower in temporal cortex (Brodmann area 38, by 19%) and beta 1-adrenoceptors (Brodmann area 21/22, by 17%) compared to controls. Suicides who died by violent means had significantly lower numbers of total beta- and beta 1-adrenoceptors in frontal cortex than matched controls (by 23 and 25%, respectively) and than non-violent suicides (by 20 and 22%, respectively) and lower numbers of beta 1-adrenoceptors in temporal cortex (Brodmann area 21/22) than matched controls (by 16%). Depressed suicides who died by non-violent means had lower numbers of total beta-adrenoceptors in occipital cortex than matched controls (by 24%) and than violent suicides (by 18%), and lower numbers of total beta- and beta 1-adrenoceptors in temporal cortex (Brodmann area 38) than matched controls (by 27 and 24%, respectively). Depression in suicide victims is associated with deficits in beta-adrenoceptor binding sites, largely restricted to cortical areas.
通过对21例有明确抑郁症回顾性诊断、近期未服用抗抑郁药物的自杀受害者以及20例年龄和性别匹配的对照者的9个脑区进行[3H]CGP 12177饱和结合实验，对β-肾上腺素能受体结合位点进行定量分析。与对照组相比，抑郁自杀者颞叶皮质（布罗德曼38区，降低19%）和β1-肾上腺素能受体（布罗德曼21/22区，降低17%）的总β-肾上腺素能受体数量显著减少。暴力自杀者额叶皮质的总β-和β1-肾上腺素能受体数量显著低于匹配对照组（分别降低23%和25%），也低于非暴力自杀者（分别降低20%和22%），颞叶皮质（布罗德曼21/22区）的β1-肾上腺素能受体数量低于匹配对照组（降低16%）。非暴力死亡的抑郁自杀者枕叶皮质的总β-肾上腺素能受体数量低于匹配对照组（降低24%），也低于暴力自杀者（降低18%），颞叶皮质（布罗德曼38区）的总β-和β1-肾上腺素能受体数量低于匹配对照组（分别降低27%和24%）。自杀受害者的抑郁症与β-肾上腺素能受体结合位点的缺陷有关，主要局限于皮质区域。
