Parker L A, Limebeer C L, Simpson G R
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Pharmacol Biochem Behav. 1998 Jan;59(1):33-7. doi: 10.1016/s0091-3057(97)00333-x.
The hedonic properties of chlordiazepoxide (CDP) were examined using the place conditioning and the taste conditioning paradigms. Following four conditioning trials, CDP (5-20 mg/kg) produced a conditioned place aversion in an "unbiased" paradigm in which the chamber paired with CDP was counterbalanced among two equally preferred chambers. In a "biased" place-conditioning paradigm, CDP (5 and 20 mg/ kg) prevented the dissipation of the natural aversion to the nonpreferred chamber. Finally, although CDP unconditionally potentiated sucrose consumption, it produced a sucrose aversion in the taste reactivity test and sucrose avoidance in the taste avoidance test when the taste conditionally preceded injections of CDP. The pattern of findings suggest that, when novel to rats, CDP is hedonically aversive.
使用位置条件反射和味觉条件反射范式研究了氯氮卓（CDP）的享乐特性。经过四次条件反射试验后，在“无偏差”范式中，CDP（5 - 20毫克/千克）产生了条件性位置厌恶，在该范式中，与CDP配对的实验箱在两个同等偏好的实验箱中进行了平衡处理。在“有偏差”的位置条件反射范式中，CDP（5和20毫克/千克）阻止了对非偏好实验箱的自然厌恶的消散。最后，尽管CDP无条件地增强了蔗糖消耗，但在味觉反应性测试中，当味觉在注射CDP之前有条件地呈现时，它产生了蔗糖厌恶，在味觉回避测试中产生了蔗糖回避。研究结果模式表明，当对大鼠来说是新事物时，CDP在享乐方面是厌恶的。
