芬氟拉明在三选一装置中诱导的位置厌恶。

Fenfluramine-induced place aversion in a three-choice apparatus.

作者信息

Davies A M, Parker L A

机构信息

Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.

出版信息

Pharmacol Biochem Behav. 1993 Mar;44(3):595-600. doi: 10.1016/0091-3057(93)90172-p.

DOI:10.1016/0091-3057(93)90172-p

PMID:8451263

Abstract

The hedonic properties of the anorectic agent fenfluramine (0.25, 1.0, 2.5, 5.0, and 10.0 mg/kg) were assessed in two experiments in a place conditioning paradigm. After four conditioning trials, rats were tested for their preference for a drug-paired chamber, saline-paired chamber, and a novel chamber. Fenfluramine produced a place aversion at doses of 2.5-10 mg/kg.

摘要

在两项实验中，采用条件性位置偏好范式评估了食欲抑制剂芬氟拉明（0.25、1.0、2.5、5.0和10.0mg/kg）的享乐特性。经过四次条件化试验后，测试大鼠对与药物配对的箱体、与生理盐水配对的箱体和新箱体的偏好。芬氟拉明在2.5-10mg/kg剂量时产生位置厌恶。