Fernández-Guasti A, Picazo O, Ferreira A
Departamento de Farmacología y Toxicología, CINVESTAV and Instituto Mexicano de Psiquiatría, México D.F., México.
Pharmacol Biochem Behav. 1998 Jan;59(1):45-50. doi: 10.1016/s0091-3057(97)00392-4.
The anxiolytic action of 8-OH-DPAT (0.125, 0.5, and 0.75 mg/kg, I.P., -15 min) was evaluated in ovariectomized and 7-day lactating mother rats. This serotonergic anxiolytic produces a clear reduction in cumulative burying behavior and in freezing time (parameters denoting a reduction in anxiety levels) in ovariectomized subjects. However, in 7-day lactating mother rats, 8-OH-DPAT lacked its antianxiety effects. Additionally, as an extra parameter of the animal's emotionality the number of defecation bolus was registered. A reduction in this parameter in ovariectomized animals after 8-OH-DPAT (0.5 mg/kg) injection was found. This effect was also blocked in 7-day lactating rats. None of the doses of the compound tested altered the burying behavior latency (a parameter inversely representing the animal's reactivity). The general ambulatory behavior of ovariectomized subjects was significantly impaired at the highest dose (0.75 mg/kg) of 8-OH-DPAT. Lower doses did not alter this parameter or the number of times lines are crossed (a parameter denoting exploratory activity). Discussion is focused on the relationship between the activity of the serotonergic system and the secretion of prolactin in this period.
在去卵巢大鼠和产后7天的哺乳期母鼠中评估了8-羟基二丙胺基四氢萘（8-OH-DPAT，腹腔注射，剂量为0.125、0.5和0.75mg/kg，给药时间为-15分钟）的抗焦虑作用。这种血清素能抗焦虑药物能使去卵巢大鼠的累积埋土行为和僵住时间（表示焦虑水平降低的参数）明显减少。然而，在产后7天的哺乳期母鼠中，8-OH-DPAT没有抗焦虑作用。此外，作为动物情绪的一个额外参数，记录了排便团块的数量。发现注射8-OH-DPAT（0.5mg/kg）后去卵巢动物的这一参数有所降低。在产后7天的哺乳期大鼠中，这种作用也被阻断。所测试的该化合物的任何剂量均未改变埋土行为潜伏期（一个反向表示动物反应性的参数）。在8-OH-DPAT的最高剂量（0.75mg/kg）下，去卵巢大鼠的一般走动行为明显受损。较低剂量未改变该参数或穿越线条的次数（一个表示探索活动的参数）。讨论集中在这一时期血清素能系统的活性与催乳素分泌之间的关系上。
