Picazo Ofir, Estrada-Camarena Erika, Hernandez-Aragon Azucena
Escuela Superior de Medicina del IPN Plan de San Luis y Diaz Mirón, Col. Sto. Tomás, México DF.
Eur J Pharmacol. 2006 Jan 13;530(1-2):88-94. doi: 10.1016/j.ejphar.2005.11.024. Epub 2005 Dec 13.
This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats ovariectomized 3, 6 and 12 weeks previously, were tested in the burying behaviour paradigm and in an automatic activity counter. The highest values of time spent burying were observed in the 12-week group. In general, the 12-week group was more responsive to diazepam than the 3-week group, while 8-OH-DPAT showed similar effects on time spent burying, independently of how long ago the ovariectomy was done. Detection of anxiogenic-like behaviours by the shock-probe burying test in rats after chronic absence of gonadal hormones could help in the understanding of mood changes associated with human menopause.
本研究分析了卵巢切除术对大鼠基础实验性焦虑的长期影响，以及这种状况对安定和5-羟色胺（1A）受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）抗焦虑特性的影响。对3周、6周和12周前进行卵巢切除的大鼠，采用埋埋行为范式和自动活动计数器进行测试。在12周组中观察到最长的埋埋时间。总体而言，12周组比3周组对安定的反应更强，而8-OH-DPAT对埋埋时间的影响相似，与卵巢切除的时间无关。通过电击探针埋埋试验检测慢性缺乏性腺激素的大鼠的焦虑样行为，有助于理解与人类更年期相关的情绪变化。
