Xiong X, Flores C, Fuller M D, Mendel D B, Mulato A S, Moon K, Chen M S, Cherrington J M
Gilead Sciences, Foster City, CA 94404, USA.
Antiviral Res. 1997 Nov;36(2):131-7. doi: 10.1016/s0166-3542(97)00050-8.
PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phosphorylated to PMEApp in numerous human cell lines. In vitro replication of wild type and drug resistant HCMV clinical isolates is effectively inhibited by PMEA. PMEA in combination with other anti-HCMV agents shows additive inhibition of HCMV replication.
