• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

骨衰减在脑单光子发射计算机断层显像定量分析中的重要性。

Importance of bone attenuation in brain SPECT quantification.

作者信息

Stodilka R Z, Kemp B J, Prato F S, Nicholson R L

机构信息

Department of Nuclear Medicine and Magnetic Resonance, St. Joseph's Health Centre, London, Ontario, Canada.

出版信息

J Nucl Med. 1998 Jan;39(1):190-7.

PMID:9443760
Abstract

UNLABELLED

The purpose of this study was to determine the effects of nonuniform attenuation on relative quantification in brain SPECT and to compare the ability of the Chang and Sorenson uniform attenuation corrections (UACs) to achieve volumetric relative quantification.

METHODS

Three head phantoms (dry human skull, Rando and Radiology Support Devices (RSD) phantoms) were compared with a human head using a gamma camera transmission CT (gammaTCT) SPECT system and x-ray CT. Subsequently, the RSD phantom's brain reservoir was filled with a uniform water solution of 99mTc, and SPECT and gammaTCT data were acquired using fanbeam collimation. The attenuating effects of bone, scalp and head-holder in individual projections were determined by an analytical projection technique using the SPECT and gammaTCT reconstructions. The Chang UAC used brain and head contours that were segmented from the gammaTCT reconstruction to demarcate its attenuation map, whereas the Sorenson UAC fit slice-specific ellipses to the SPECT projection data. For each UAC, volumetric relative quantification was measured with varying attenuation coefficients (mus) of the attenuation map.

RESULTS

Gamma camera transmission CT and x-ray CT scans showed that the dry skull and Rando phantoms suffered from a dried trabecular bone compartment. The RSD phantom most closely reproduced the attenuation coefficients of the human gammaTCT and x-ray CT scans. The analytical projections showed that the attenuating effects of bone, scalp and head-holder were nonuniform across the projections and accounted for 18%-37% of the total count loss. Volumetric relative quantification was best achieved with the Chang (zero iterations) attenuation correction using the head contour and mu = 0.075 cm(-1); however, cortical activity was found to be 10% higher than cerebellar activity. For all UACs, the optimal choices of mu were experimentally found to be lower than the recommended 0.12 cm(-1) for brain tissue. This result is theoretically supported here.

CONCLUSION

The magnitude of errors resulting from uniform attenuation corrections can be greater than the magnitudes of regional cerebral blood flow deficits in patients with dementia, as compared with normal controls. This suggests that nonuniform attenuation correction in brain SPECT imaging must be applied to accurately estimate regional cerebral blood flow.

摘要

未标注

本研究的目的是确定非均匀衰减对脑SPECT相对定量的影响,并比较张和索伦森均匀衰减校正(UAC)实现体积相对定量的能力。

方法

使用伽马相机透射CT(gammaTCT)SPECT系统和X射线CT,将三个头部模型(干燥的人类头骨、兰多模型和放射学支持设备(RSD)模型)与一个人类头部进行比较。随后,在RSD模型的脑池内注入均匀的99mTc水溶液,使用扇形束准直采集SPECT和gammaTCT数据。通过使用SPECT和gammaTCT重建的分析投影技术,确定各个投影中骨骼、头皮和头托的衰减效应。张UAC使用从gammaTCT重建中分割出的脑和头部轮廓来划定其衰减图,而索伦森UAC则将特定切片的椭圆拟合到SPECT投影数据上。对于每种UAC,在衰减图的衰减系数(μ)变化的情况下测量体积相对定量。

结果

伽马相机透射CT和X射线CT扫描显示,干燥的头骨和兰多模型存在干燥的小梁骨腔。RSD模型最接近地再现了人类gammaTCT和X射线CT扫描的衰减系数。分析投影显示,骨骼、头皮和头托的衰减效应在各个投影中是不均匀的,占总计数损失的18%-37%。使用头部轮廓且μ = 0.075 cm(-1)的张(零迭代)衰减校正能最好地实现体积相对定量;然而,发现皮质活性比小脑活性高10%。对于所有UAC,通过实验发现μ的最佳选择低于脑组织推荐的0.12 cm(-1)。本文从理论上支持了这一结果。

结论

与正常对照相比,均匀衰减校正导致的误差幅度可能大于痴呆患者局部脑血流缺损的幅度。这表明在脑SPECT成像中必须应用非均匀衰减校正来准确估计局部脑血流。

相似文献

1
Importance of bone attenuation in brain SPECT quantification.骨衰减在脑单光子发射计算机断层显像定量分析中的重要性。
J Nucl Med. 1998 Jan;39(1):190-7.
2
Nonuniform transmission in brain SPECT using 201Tl, 153Gd, and 99mTc static line sources: anthropomorphic dosimetry studies and influence on brain quantification.使用201铊、153钆和99m锝静态线源进行脑单光子发射计算机断层扫描中的非均匀传输:人体剂量学研究及其对脑定量的影响
J Nucl Med. 2000 Dec;41(12):2051-62.
3
Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans.99mTc单光子发射计算机断层扫描脑成像中的衰减补偿:正常扫描中基于透射数据与发射数据的衰减图应用比较
J Nucl Med. 1999 Mar;40(3):456-63.
4
Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT.散射和衰减校正对单光子发射计算机断层扫描定量评估局部脑血流的影响。
J Nucl Med. 1998 Jan;39(1):181-9.
5
Impact of CT attenuation correction by SPECT/CT in brain perfusion images.SPECT/CT 对脑灌注图像 CT 衰减校正的影响。
Ann Nucl Med. 2012 Apr;26(3):241-7. doi: 10.1007/s12149-011-0567-y. Epub 2012 Jan 26.
6
Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system.针对体部轮廓SPECT/CT成像系统的光子衰减和准直器响应校正。
J Nucl Med. 2005 May;46(5):868-77.
7
Significance of nonuniform attenuation correction in quantitative brain SPECT imaging.定量脑单光子发射计算机断层扫描成像中不均匀衰减校正的意义。
J Nucl Med. 1998 Oct;39(10):1719-26.
8
Scatter and attenuation correction for brain SPECT using attenuation distributions inferred from a head atlas.
J Nucl Med. 2000 Sep;41(9):1569-78.
9
Influence of Attenuation Correction by Brain Perfusion SPECT/CT Using a Simulated Abnormal Bone Structure: Comparison Between Chang and CT Methods.使用模拟异常骨结构的脑灌注SPECT/CT进行衰减校正的影响:Chang法与CT法的比较
J Nucl Med Technol. 2017 Sep;45(3):208-213. doi: 10.2967/jnmt.117.189506. Epub 2017 Jul 13.
10
Transmission imaging for nonuniform attenuation correction using a three-headed SPECT camera.使用三头单光子发射计算机断层显像(SPECT)相机进行非均匀衰减校正的透射成像。
J Nucl Med. 1998 Jun;39(6):1105-10.

引用本文的文献

1
Role and limitations of the geometric mean method regarding head rotation in salivary gland scintigraphy: a phantom study.关于唾液腺闪烁显像中头旋转的几何均数法的作用和局限性:一项体模研究。
J Radiat Res. 2020 Sep 8;61(5):697-704. doi: 10.1093/jrr/rraa046.
2
Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's method.基于体素的统计分析与 Chang 法比较,利用 CT 衰减校正的脑灌注 SPECT/CT 在预测轻度认知障碍向阿尔茨海默病变化恶化方面的诊断效用和特征。
Ann Nucl Med. 2020 Jul;34(7):502-511. doi: 10.1007/s12149-020-01477-4. Epub 2020 May 24.
3
CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses.脑SPECT/CT中基于CT的衰减校正可提高基于体素的统计分析的病变可检测性。
PLoS One. 2016 Jul 21;11(7):e0159505. doi: 10.1371/journal.pone.0159505. eCollection 2016.
4
Influences of reconstruction and attenuation correction in brain SPECT images obtained by the hybrid SPECT/CT device: evaluation with a 3-dimensional brain phantom.混合型SPECT/CT设备获得的脑SPECT图像中重建和衰减校正的影响:使用三维脑体模进行评估
Asia Ocean J Nucl Med Biol. 2014 Spring;2(1):24-9.
5
Investigation of attenuation correction for small-animal single photon emission computed tomography.小动物单光子发射计算机断层成像衰减校正的研究。
Comput Math Methods Med. 2013;2013:430276. doi: 10.1155/2013/430276. Epub 2013 Jun 11.
6
Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour.包含骨和灰质结构的三维脑模型,具有逼真的头部轮廓。
Ann Nucl Med. 2013 Jan;27(1):25-36. doi: 10.1007/s12149-012-0655-7. Epub 2012 Sep 26.
7
The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification.基于CT的衰减校正和准直器模糊校正在纹状体光谱定量分析中的作用
Int J Mol Imaging. 2011;2011:195037. doi: 10.1155/2011/195037. Epub 2011 Apr 6.
8
Cross-camera comparison of SPECT measurements of a 3-D anthropomorphic basal ganglia phantom.三维拟人化基底神经节体模SPECT测量的跨相机比较。
Eur J Nucl Med Mol Imaging. 2006 Apr;33(4):495-502. doi: 10.1007/s00259-005-0036-8. Epub 2006 Jan 25.
9
Attenuation compensation in cerebral 3D PET: effect of the attenuation map on absolute and relative quantitation.脑部三维正电子发射断层显像中的衰减补偿:衰减图对绝对定量和相对定量的影响
Eur J Nucl Med Mol Imaging. 2004 Jan;31(1):52-63. doi: 10.1007/s00259-003-1325-8. Epub 2003 Oct 22.
10
Which attenuation coefficient to use in combined attenuation and scatter corrections for quantitative brain SPET?在定量脑单光子发射计算机断层显像(SPET)的衰减与散射校正中应使用哪种衰减系数?
Eur J Nucl Med Mol Imaging. 2002 Jul;29(7):967-9; author reply 969-70. doi: 10.1007/s00259-002-0840-3.