乙肝携带者母亲的新生儿存在宫内乙肝病毒感染的证据吗？

Is there evidence for intrauterine HBV infection in newborns of hepatitis B carrier mothers?

作者信息

Poovorawan Y, Chongsrisawat V, Theamboonlers A, Vimolkej L, Yano M

机构信息

Viral Hepatitis Research Unit, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1997 Jun;28(2):365-9.

PMID:9444022

Abstract

It has been proposed that some neonates infected with hepatitis B virus (HBV), acquire their infections in utero as demonstrated by HBV seromarkers in venous blood samples at birth. In this study, paired blood samples from 13 HBsAg-positive, 19 HBsAg- and HBeAg-positive, 2 HBsAg-negative mothers and 34 of their neonates, were drawn 24-72 hours after birth and tested for HBV-DNA in their peripheral blood mononuclear cells (PBMC). The presence of HBV-DNA in PBMC was detected in 69.2% (9/13) of HBsAg-positive mothers, 94.7% (18/19) of HBsAg- and HBeAg-positive mothers, and in none of their neonates. The conclusion from these results is that the evidence for hepatitis B infections occurring in neonates of hepatitis B carrier mothers in utero is uncommon.

摘要

有人提出，一些感染乙型肝炎病毒（HBV）的新生儿是在子宫内感染的，这一点可通过出生时静脉血样本中的HBV血清标志物得到证明。在本研究中，采集了13名HBsAg阳性、19名HBsAg和HBeAg阳性母亲及其34名新生儿出生后24至72小时的配对血样，并检测其外周血单个核细胞（PBMC）中的HBV-DNA。在HBsAg阳性母亲中，69.2%（9/13）的PBMC中检测到HBV-DNA；在HBsAg和HBeAg阳性母亲中，94.7%（18/19）的PBMC中检测到HBV-DNA，而在她们的新生儿中均未检测到。这些结果得出的结论是，乙肝携带者母亲的新生儿在子宫内发生乙肝感染的证据并不常见。