Swann A, O'Brien J, Ames D, Schweitzer I, Desmond P, Tress B
Brighton Clinic, Newcastle upon Tyne, UK.
Int J Geriatr Psychiatry. 1997 Dec;12(12):1182-8.
To investigate whether the presence of hippocampal atrophy (HCA) on MRI in Alzheimer's disease (AD) leads to a more rapid decline in cognitive function. To investigate whether cognitively unimpaired controls and depressed subjects with HCA are at higher risk than those without HCA of developing dementia.
A prospective follow-up of subjects from a previously reported MRI study.
Melbourne, Australia.
Five controls with HCA and five age-matched controls without HCA, seven depressed subjects with HCA and seven without HCA, and 12 subjects with clinically diagnosed probable AD with HCA and 12 without HCA were studied. They were followed up at approximately 2 years with repeat cognitive testing, blind to initial diagnosis and MRI result.
HCA was rated by two radiologists blind to cognitive test score results. Cognitive assessment was by the Cambridge Cognitive Examination (CAMCOG).
No significant differences in rate of cognitive decline, mortality or progression to dementia were found between subjects with or without HCA.
HCA was not found to be a predictor of subsequent cognitive decline in this series.
研究阿尔茨海默病（AD）患者磁共振成像（MRI）显示的海马萎缩（HCA）是否会导致认知功能更快下降。研究认知功能未受损的对照者以及伴有HCA的抑郁患者相较于无HCA者发生痴呆的风险是否更高。
对先前一项MRI研究中的受试者进行前瞻性随访。
澳大利亚墨尔本。
研究了5名伴有HCA的对照者和5名年龄匹配的无HCA对照者，7名伴有HCA的抑郁患者和7名无HCA的抑郁患者，以及12名临床诊断为可能患有AD且伴有HCA的受试者和12名无HCA的受试者。对他们进行了约2年的随访，重复进行认知测试，且测试人员对初始诊断和MRI结果不知情。
由两名对认知测试分数结果不知情的放射科医生对HCA进行评分。通过剑桥认知检查（CAMCOG）进行认知评估。
有或无HCA的受试者在认知下降速度、死亡率或发展为痴呆方面未发现显著差异。
在本研究系列中，未发现HCA是后续认知下降的预测因素。
